Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87484
Type: Artigo de periódico
Title: Efficient And Practical Procedure For The Esterification Of The Free α-carboxylic Acid Of Amino Acid Residues With β-(trimethylsilyl)ethoxymethyl Chloride And Triisopropylsilyl Chloride
Author: Suppo J.-S.
De Sant'Ana D.P.
Dias L.C.
De Figueiredo R.M.
Campagne J.-M.
Abstract: An efficient and practical procedure for the free α-carboxylic acid esterification of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride is described. The reaction takes place under mild conditions and the expected protected amino acids are obtained in good to excellent yields. Our method provides a useful alternative for the C-terminal carboxylic acid protection of amino acids and peptides. Moreover, the removal of such protection was also achieved under mild conditions, without affecting either the other protecting groups at the α-amino moiety and side chains or the optical integrity at the α-position of the amino acid residues. Examples of their use in peptide synthesis are also illustrated.
Editor: Georg Thieme Verlag
Rights: aberto
Identifier DOI: 10.1055/s-0034-1379004
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84911899566&partnerID=40&md5=05b9f185e7170dfec29d511aa6697047
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84911899566.pdf330.9 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.