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Type: Artigo de periódico
Title: Biomarkers Of Oxidative Stress In Patients With Chronic Respiratory Insuficiency (cresi) During Long Term Oxigen Therapy (ltot) [biomarcadores De Estresse Oxidativo Em Fumantes Crônicos E Em Portadores De Insuficiência Respiratória Crônica (iresc) Durante Oxigenoterapia Domiciliar Prolongada (odp)]
Author: El Khatib S.
Paschoal I.A.
Corso M.P.
De Macedo D.V.
Abstract: Sumary Objective: The aim of this study was to evaluate several biomarkers of oxidative stress in patients with Chronic Respiratory Insuficiency (CResI) at three moments: before, after 7 and 270 days of Long Term Oxigen Therapy (LTOT).Methods: The blood catalase (CAT), and glutathione reductase (GR), the Hemoglobin (Hb), lactate and Uric Acid concentration (AU) in total blood were measured. The total sulphydrils (TSH) and Protein carbonyls concentration were measured in plasma in these patients, using spectrophotometric techniques. The blood oxygen saturation (SpO2) was evaluated using a pulse oxymeter.Results: When compared Chronic Smokers (CS) with CResI group and both with Nonsmokers group (NS) observed that CResI group presented an increase in oxidative stress level, represented for decrease of three biomarkers: CAT, GR and TSH. After 7 days of LTOT the SpO2, CAT and GR activity and AU concentration were increased (P<0,05). On the other hand, the decrease on GST concentration was manteined in this period (P<0,05). The pacients submitted of 7 to 270 of LTOT showed a significant decrease on GR activity (P<0.05).Conclusion: These results showed that the major level of oxidative stress in patients with CResI happened probably as consequence of chronic hypoxemia and the LTOT was not able to block the clinic evolution of disease. © Copyright Moreira Jr. Editora.
Editor: Moreira Junior Editora Ltda.
Rights: fechado
Identifier DOI: 
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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