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Type: Artigo de periódico
Title: In Silico Phylogenetic And Virulence Gene Profile Analyzes Of Avian Pathogenic Escherichia Coli Genome Sequences [in Silico Phylogenetic And Virulence Gene Profile Analyses Of Avian Pathogenic Escherichia Coli Genome Sequences]
Author: Rojas T.C.G.
Maluta R.P.
Koenigkan L.V.
Da Silveira W.D.
Abstract: Avian pathogenic Escherichia coli (APEC) infections are responsible for significant losses in the poultry industry worldwide. A zoonotic risk has been attributed to APEC strains because they present similarities to extraintestinal pathogenic E. coli (ExPEC) associated with illness in humans, mainly urinary tract infections and neonatal meningitis. Here, we present in silico analyses with pathogenic E. coli genome sequences, including recently available APEC genomes. The phylogenetic tree, based on multi-locus sequence typing (MLST) of seven housekeeping genes, revealed high diversity in the allelic composition. Nevertheless, despite this diversity, the phylogenetic tree was able to cluster the different pathotypes together. An in silico virulence gene profile was also determined for each of these strains, through the presence or absence of 83 well-known virulence genes/traits described in pathogenic E. coli strains. The MLST phylogeny and the virulence gene profiles demonstrated a certain genetic similarity between Brazilian APEC strains, APEC isolated in the United States, UPEC (uropathogenic E. coli) and diarrheagenic strains isolated from humans. This correlation corroborates and reinforces the zoonotic potential hypothesis proposed to APEC.
Editor: Colegio Brasileiro de Patologia Animal
Rights: aberto
Identifier DOI: 10.1590/S0100-736X2014000200006
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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