Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86967
Type: Artigo de periódico
Title: Phylogenetic Analysis Of The Gst Family In Anopheles (nyssorhynchus) Darlingi
Author: Azevedo-Junior G.M.D.
Guimaraes-Marques G.M.
Cegatti Bridi L.
Christine Ohse K.
Vicentini R.
Tadei W.
Rafael M.S.
Abstract: Anopheles darlingi Root, 1926 and Anopheles gambiae (Diptera: Culicidae) are the most important human malaria vectors in South America and Africa, respectively. The two species are estimated to have diverged 100 million years ago. Studies on the phylogenetics and evolution of gene sequences, such as glutathione S-transferase (GST) in disease-transmitting mosquitoes are scarce. The sigma class GST (KC890767) from the transcriptome of An. darlingi captured in the Brazilian Amazon was studied by in silico hybridization, and mapped to chromosome 3 of An. gambiae. The sigma class GST of An. darlingi was used for phylogenetic analyses to understand the GST base composition of the most recent common ancestor between An. darlingi, Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus. The GST (KC890767) of An. darlingi was studied to generate the main divergence branches using a Neighbor-Joining and bootstrapping approaches to confirm confidence levels on the tree nodes that separate the An. darlingi and other mosquito species. The results showed divergence between An. gambiae, Ae. Aegypti, Cx. quinquefasciatus, and Phlebotomus papatasi as outgroup, and the homology relationship between sigma class GST of An. darlingi and GSTS1_1 gene of An. gambiae was valuable for phylogenetic and evolutionary studies. © 2014 Elsevier B.V.
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.actatropica.2014.03.027
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899892643&partnerID=40&md5=1e9fe5c7215f829972dd4e35752a8773
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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