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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Gleidy Ana Araujopt_BR
dc.contributor.authorunicampPradella, Fernandopt_BR
dc.contributor.authorunicampMoraes, Adriel dos Santospt_BR
dc.contributor.authorunicampFarias, Alessandro dos Santospt_BR
dc.contributor.authorunicampSantos, Leonilda Maria Barbosa dospt_BR
dc.contributor.authorunicampOliveira, Alexandre Leite Rodrigues dept_BR
dc.typeArtigopt_BR
dc.titleImpact of pregabalin treatment on synaptic plasticity and glial reactivity during the course of experimental autoimmune encephalomyelitispt_BR
dc.contributor.authorSilva, Gleidy A. A.pt_BR
dc.contributor.authorPradella, Fernandopt_BR
dc.contributor.authorMoraes, Adrielpt_BR
dc.contributor.authorFarias, Alessandropt_BR
dc.contributor.authorSantos, Leonilda, M. B. dospt_BR
dc.contributor.authorOliveira, Alexandre L. R. dept_BR
unicamp.authorSilva, G.A.A., Laboratory of Nerve Regeneration, Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
unicamp.authorPradella, F., Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazil, Neuroimmunomodulation Group, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
unicamp.authorMoraes, A., Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazil, Neuroimmunomodulation Group, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
unicamp.authorFarias, A., Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazil, Neuroimmunomodulation Group, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
unicamp.authordos Santos, L.M.B., Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
unicamp.authorde Oliveira, A.L.R., Laboratory of Nerve Regeneration, Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMPCampinas, SP, Brazilpt_BR
dc.subjectEncefalomielite autoimune experimentalpt_BR
dc.subjectPregabalinapt_BR
dc.subjectNeurônios motorespt_BR
dc.subjectSinapsept_BR
dc.subject.otherlanguageEncephalomyelitis, Autoimmune, Experimentalpt_BR
dc.subject.otherlanguagePregabalinpt_BR
dc.subject.otherlanguageMotor neuronspt_BR
dc.subject.otherlanguageSynapsespt_BR
dc.description.abstractBackground: Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease that affects young adults. It is characterized by generating a chronic demyelinating autoimmune inflammation in the central nervous system. An experimental model for studying MS is the experimental autoimmune encephalomyelitis (EAE), induced by immunization with antigenic proteins from myelin. Aims: The present study investigated the evolution of EAE in pregabalin treated animals up to the remission phase. Methods and results: The results demonstrated a delay in the onset of the disease with statistical differences at the 10th and the 16th day after immunization. Additionally, the walking track test (CatWalk) was used to evaluate different parameters related to motor function. Although no difference between groups was obtained for the foot print pressure, the regularity index was improved post treatment, indicating a better motor coordination. The immunohistochemical analysis of putative synapse preservation and glial reactivity revealed that pregabalin treatment improved the overall morphology of the spinal cord. A preservation of circuits was depicted and the glial reaction was downregulated during the course of the disease. qRT-PCR data did not show immunomodulatory effects of pregabalin, indicating that the positive effects were restricted to the CNS environment. Conclusions: Overall, the present data indicate that pregabalin is efficient for reducing the seriousness of EAE, delaying its course as well as reducing synaptic loss and astroglial reaction.en
dc.description.abstractMultiple sclerosis (MS) is an autoimmune and neurodegenerative disease that affects young adults. It is characterized by generating a chronic demyelinating autoimmune inflammation in the central nervous system. An experimental model for studying MS is thept_BR
dc.relation.ispartofBrain and Behaviorpt_BR
dc.relation.ispartofabbreviationBrain behav.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationNov.pt_BR
dc.identifier.citationBrain And Behavior. John Wiley And Sons Ltd, v. 4, n. 6, p. 925 - 935, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume4pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage925pt_BR
dc.description.lastpage935pt_BR
dc.rightsfechadopt_BR
dc.rightsfechadopt_br
dc.sourceSCOPUSpt_BR
dc.identifier.issn2162-3279pt_BR
dc.identifier.doi10.1002/brb3.276pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.276pt_BR
dc.description.sponsorshipCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORpt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2015-06-25T17:55:46Z
dc.date.available2015-11-26T14:40:58Z-
dc.date.accessioned2015-06-25T17:55:46Z
dc.date.accessioned2015-11-26T14:40:58Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T14:40:58Z (GMT). No. of bitstreams: 2 2-s2.0-84911434558.pdf: 3542500 bytes, checksum: df0e962faa5e5024c45243a3f4f799e1 (MD5) 2-s2.0-84911434558.pdf.txt: 39738 bytes, checksum: f0f20b1617acc167772e372ff8d0a405 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/86904
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86904-
dc.identifier.idScopus2-s2.0-84911434558pt_BR
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dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Engenharia Elétrica e de Computaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordExperimental autoimmune encephalomyelitispt_BR
dc.subject.keywordSpinal motoneuronspt_BR
dc.subject.keywordSynapsept_BR
dc.identifier.source2-s2.0-84911434558pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-9365-573Xpt_BR
dc.creator.orcid0000-0001-6759-1819pt_BR
dc.creator.orcid0000-0002-3600-9205pt_BR
dc.creator.orcid0000-0003-4224-4575pt_BR
dc.type.formArtigo Originalpt_BR
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