Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86894
Type: Artigo de periódico
Title: Plasma Fibrinogen: Now Also An Antidepressant Response Marker?
Author: Martins-De-Souza D.
Maccarrone G.
Ising M.
Kloiber S.
Lucae S.
Holsboer F.
Turck C.W.
Abstract: Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk factor for noncompliance with medical treatment, with about 40% of patients not responding to currently used antidepressant drugs. The identification and clinical implementation of biomarkers that can indicate the likelihood of treatment response are needed in order to predict which patients will benefit from an antidepressant drug. While analyzing the blood plasma proteome collected from MDD patients before the initiation of antidepressant medication, we observed different fibrinogen alpha (FGA) levels between drug responders and nonresponders. These results were replicated in a second set of patients. Our findings lend further support to a recently identified association between MDD and fibrinogen levels from a large-scale study. © 2014 Macmillan Publishers Limited.
Editor: 
Rights: aberto
Identifier DOI: 10.1038/tp.2013.129
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84893354179&partnerID=40&md5=682e1005f30c4b9d201f1d388a60898d
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84893354179.pdf337.09 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.