Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86854
Type: Artigo de periódico
Title: Stathmin 1 In Normal And Malignant Hematopoiesis
Author: Machado-Neto J.A.
Saad S.T.O.
Traina F.
Abstract: Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. The scope of the present review is to survey the current knowledge and highlight future perspectives for Stathmin 1 in normal and malignant hematopoiesis, with regard to the expression, function and clinical implications of this protein.
Editor: The Biochemical Society of the Republic of Korea
Rights: fechado
Identifier DOI: 10.5483/BMBRep.2014.47.12.020
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922274764&partnerID=40&md5=cb0a62be1593d7785235ae21fa8bcf9f
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84922274764.pdf3.94 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.