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Type: Artigo de periódico
Title: Stathmin 1 In Normal And Malignant Hematopoiesis
Author: Machado-Neto J.A.
Saad S.T.O.
Traina F.
Abstract: Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. The scope of the present review is to survey the current knowledge and highlight future perspectives for Stathmin 1 in normal and malignant hematopoiesis, with regard to the expression, function and clinical implications of this protein.
Editor: The Biochemical Society of the Republic of Korea
Rights: fechado
Identifier DOI: 10.5483/BMBRep.2014.47.12.020
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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