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Type: Artigo de periódico
Title: Fast Detection Of Paracetamol On A Gold Nanoparticle-chitosan Substrate By Sers
Author: Santos E.D.B.
Lima E.C.N.L.
Oliveira C.S.D.
Sigoli F.A.
Mazali I.O.
Abstract: A fast method for detecting pharmaceutical drugs, such as paracetamol, by surface-enhanced Raman spectroscopy (SERS) using a gold nanoparticle substrate was studied. Gold nanoparticles were synthesized using chitosan (AuNP-chitosan) as a reductant and capping agent and subsequently deposited on glass slides as a thin film. The SERS performance of AuNP-chitosan films was evaluated using methylene blue (MB, 10-6 mol L-1) as a SERS probe molecule. The method is based on drop-drying an analyte solution (paracetamol, 10-3 mol L-1) onto a substrate surface and subsequently analyzing by Raman spectroscopy. The spectra were obtained in 10 seconds with two accumulations and exhibit a high signal-to-noise ratio. This preliminary study supports the AuNP-chitosan substrate as a SERS sensor, for a convenient analytical method for detection of paracetamol and other pharmaceutical drug molecules. © the Partner Organisations 2014.
Editor: Royal Society of Chemistry
Rights: aberto
Identifier DOI: 10.1039/c4ay00635f
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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