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Type: Artigo de periódico
Title: Lipopolysaccharide Influences On The Toxicity Of Oxidised Multiwalled Carbon Nanotubes To Murine Splenocytes In Vitro
Author: Barbosa G.M.
Fagan S.B.
Martinez D.S.T.
Alves O.L.
Rodrigues Junior L.C.
Abstract: This experimental study evaluated the influence of the presence of lipopolysaccharide (LPS), a common bacterial endotoxin, on the nitric acid oxidised multiwalled carbon nanotubes (Ox-MWCNT) during the assessment of in vitro toxicity to splenocytes, an immune system cell isolated from BALB/c mice. The concentration of LPS was determined by Limulus Amebocyte assay and this endotoxin was removed from Ox-MWCNT by using three cycles of autoclave. Splenocytes were cultured in RPMI 1640 media with 1.0, 5.0 or 10 ng/mL of Ox-MWCNT. The results showed that the presence of LPS on Ox-MWCNT did not affect the growth of splenocytes in vitro. However, the absence of LPS decreased the splenocytes viability significantly. © 2014 © 2014 Taylor & Francis.
Rights: fechado
Identifier DOI: 10.1080/17458080.2014.888788
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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