Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86598
Type: Artigo
Title: Nanostructured porous silicon-mediated drug delivery
Author: Martin-Palma R. J.
Hernandez-Montelongo J.
Torres-Costa V.
Manso-Silvan M.
Munoz-Noval A.
Abstract: Introduction: The particular properties of nanostructured porous silicon (nanoPS) make it an attractive material for controlled and localized release of therapeutics within the body, aiming at increased efficacy and reduced risks of potential side effects. Since this is a rapidly evolving field as a consequence of the number of research groups involved, a critical review of the state of the art is necessary. Areas covered: In this work, the most promising and successful applications of nanoPS in the field of drug delivery are reviewed and discussed. Two key issues such as drug loading and release are also analyzed in detail. The development of multifunctional (hybrid) systems, aiming at imparting additional functionalities to the nanoPS particles such as luminescence, magnetic response and/or plasmonic effects (allowing simultaneous tracking and guiding), is also examined. Expert opinion: Nanostructured materials based on silicon are promising platforms for pharmaceutical applications given their ability to degrade and low toxicity. However, a very limited number of clinical applications have been demonstrated so far. © 2014 Informa UK, Ltd.
The particular properties of nanostructured porous silicon (nanoPS) make it an attractive material for controlled and localized release of therapeutics within the body, aiming at increased efficacy and reduced risks of potential side effects. Since this is a rapidly evolving field as a consequence of the number of research groups involved, a critical review of the state of the art is necessary. Areas covered: In this work, the most promising and successful applications of nanoPS in the field of drug delivery are reviewed and discussed. Two key issues such as drug loading and release are also analyzed in detail. The development of multifunctional (hybrid) systems, aiming at imparting additional functionalities to the nanoPS particles such as luminescence, magnetic response and/or plasmonic effects (allowing simultaneous tracking and guiding), is also examined. Expert opinion: Nanostructured materials based on silicon are promising platforms for pharmaceutical applications given their ability to degrade and low toxicity. However, a very limited number of clinical applications have been demonstrated so far.
Subject: Sistemas híbridos
Nanoestrutura
Fotoluminescência
Silício poroso
Country: Reino Unido
Editor: Taylor & Francis
Citation: Expert Opinion On Drug Delivery. Informa Healthcare, v. 11, n. 8, p. 1273 - 1283, 2014.
Rights: fechado
Identifier DOI: 10.1517/17425247.2014.919254
Address: https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.919254
Date Issue: 2014
Appears in Collections:IFGW - Artigos e Outros Documentos

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