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Type: Artigo de periódico
Title: Diethylstilbestrol 1 Mg In The Treatment Of Acute Urinary Retention Due To Prostatic Obstruction In The Elderly: A Preliminary Study
Author: Reis L.O.
De Mendonca G.B.
Carneiro B.D.
Schneider E.
Gewehr E.V.
Meirelles A.
Denardi F.
Gugliotta A.
Abstract: Patients who failed a catheter-free trial after acute urinary retention and one week of full dose alpha-blocker and 5-alpha-reductase inhibitor were offered Diethylstilbestrol 1 mg plus Aspirin 100 mg over 4 weeks. Prostate volume, age, serum creatinine, and initial retention drained urine volume were recorded. After excluding cardiovascular morbidity (n = 7), upper urinary tract dilation (n = 3), compromised renal function (n = 2), urinary tract infection (n = 2), neurological diagnosis (n = 2), or preferred immediate channel transurethral resection of prostate (n = 5), 48 of 69 consecutive patients ≥70 years were included. Mean age was 76.6 years (70-84), mean prostate volume 90 cm3 (42-128), and mean follow-up 204 days; 58% (28/48) were passing urine and 42% (20/48) were catheter dependent after 4 weeks Diethylstilbestrol trial. Mean age and drained urine volume of catheter dependent patients were 82.4 years and 850 mL compared with 74.6 years and 530 mL in catheter-free men, respectively. Age and drained urine volume were independent predictors of catheter-free trial (both P < 0.01). Seventy-five percent (6/8) of patients 80 years and older were catheter dependent. Transient nipple/breast tenderness and gynecomastia were the only adverse effects reported by 21% (10/48) and 4% (2/48), respectively. No patient presented severe complications. © 2014 Leonardo Oliveira Reis et al.
Rights: aberto
Identifier DOI: 10.1155/2014/984382
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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