Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86558
Type: Artigo de periódico
Title: Fasn Expression, Angiogenesis And Lymphangiogenesis In Central And Peripheral Giant Cell Lesions
Author: Falci S.G.M.
Mesquita A.T.M.
de Andrade B.A.B.
de Miranda J.L.
Leon J.E.
de Almeida O.P.
dos Santos C.R.R.
Abstract: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was significantly higher than MVD-CD105, followed by MVD-D2-40. Moreover, a significantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were significantly higher in PGCL. Positive correlation between MVA-CD105 with FASN-positive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.
Editor: Faculdade de Odontologia de Bauru
Rights: aberto
Identifier DOI: 10.1590/1678-775720130509
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84896472838&partnerID=40&md5=2b65949d2c06c444b92a0addb92881d1
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84896472838.pdf2.1 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.