Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86522
Type: Artigo de periódico
Title: The Sitting Height/height Ratio For Age In Healthy And Short Individuals And Its Potential Role In Selecting Short Children For Shox Analysis
Author: Malaquias A.C.
Scalco R.C.
Fontenele E.G.P.
Costalonga E.F.
Baldin A.D.
Braz A.F.
Funari M.F.A.
Nishi M.Y.
Guerra-Junior G.
Mendonca B.B.
Arnhold I.J.P.
Jorge A.A.L.
Abstract: Aims: To determine the presence of abnormal body proportion, assessed by sitting height/height ratio for age and sex (SH/H SDS) in healthy and short individuals, and to estimate its role in selecting short children for SHOX analysis. Methods: Height, sitting height and weight were evaluated in 1,771 healthy children, 128 children with idiopathic short stature (ISS), 58 individuals with SHOX defects (SHOX-D) and 193 females with Turner syndrome (TS). Results: The frequency of abnormal body proportion, defined as SH/H SDS >2, in ISS children was 16.4% (95% CI 10-22%), which was higher than in controls (1.4%, 95% CI 0.8-1.9%, p < 0.001). The SHOX gene was evaluated in all disproportionate ISS children and defects in this gene were observed in 19%. Among patients with SHOX-D, 88% of children (95% CI 75-100%) and 96% of adults had body disproportion. In contrast, SH/H SDS >2 were less common in children (48%, 95% CI 37-59%) and in adults (28%, 95% CI 20-36%) with TS. Conclusion: Abnormal body proportions were observed in almost all individuals with SHOX-D, 50% of females with TS and 16% of children considered ISS. Defects in SHOX gene were identified in 19% of ISS children with SH/H SDS >2, suggesting that SH/H SDS is a useful tool to select children for undergoing SHOX molecular studies. © 2013 S. Karger AG, Basel.
Editor: 
Rights: fechado
Identifier DOI: 10.1159/000355411
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84893127903&partnerID=40&md5=1d3a6c2e51002ad569d2933af73a5e46
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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