Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86395
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAgostini, Michellept_BR
dc.contributor.authorunicampAlmeida, Luciana Yamamoto dept_BR
dc.contributor.authorunicampBastos, Débora Campanellapt_BR
dc.contributor.authorunicampOrtega, Rose Marapt_BR
dc.contributor.authorunicampMoreira, Fernanda dos Santospt_BR
dc.contributor.authorunicampSeguin, Fabianapt_BR
dc.contributor.authorunicampZecchin, Karina Gottardellopt_BR
dc.contributor.authorunicampRaposo, Helena Fonsecapt_BR
dc.contributor.authorunicampOliveira, Helena Coutinho Franco dept_BR
dc.contributor.authorunicampAmoêdo, Nívea Diaspt_BR
dc.contributor.authorunicampSapt_BR
dc.typeArtigopt_BR
dc.titleThe fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomaspt_BR
dc.contributor.authorAgostini, M.pt_BR
dc.contributor.authorAlmeida, L.Y.pt_BR
dc.contributor.authorBastos, D.C.pt_BR
dc.contributor.authorOrtega, R.M.pt_BR
dc.contributor.authorMoreira, F.S.pt_BR
dc.contributor.authorSeguin, F.pt_BR
dc.contributor.authorZecchin, K.G.pt_BR
dc.contributor.authorRaposo, H.F.pt_BR
dc.contributor.authorOliveira, H.C.F.pt_BR
dc.contributor.authorAmoedo, N.D.pt_BR
dc.contributor.authorSalo, T.pt_BR
dc.contributor.authorColetta, R.D.pt_BR
dc.contributor.authorGraner, E.pt_BR
unicamp.authorAgostini, M., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazil, Department of Oral Diagnosis and Pathology, School of Dentistry), Rio de Janeiro, Brazilpt_BR
unicamp.authorAlmeida, L.Y., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorBastos, D.C., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorOrtega, R.M., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorMoreira, F.S., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorSeguin, F., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorZecchin, K.G., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorRaposo, H.F., Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazilpt_BR
unicamp.authorOliveira, H.C.F., Department of Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazilpt_BR
unicamp.authorColetta, R.D., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.authorGraner, E., Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP), Avenida Limeira 901, CP 52, Areão, Piracicaba, São Paulo 13414-018, Brazilpt_BR
unicamp.author.externalAmoêdo, N.D., Institute of Medical Biochemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazilpt
unicamp.author.externalSalo, T., Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland, Oulu University Hospital, Oulu, Finland, Institute of Dentistry, University of Helsinki, Helsinki, Finlandpt
dc.subjectCarcinoma de células escamosaspt_BR
dc.subject.otherlanguageCarcinoma, squamous cellpt_BR
dc.description.abstractFatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Conversely, several human cancers, including head and neck squamous cell carcinomas (HNSCC), overexpress FASN, which has been associated with poor prognosis and recently suggested as a metabolic oncoprotein. Orlistat is an irreversible inhibitor of FASN activity with cytotoxic properties on several cancer cell lines that inhibits tumor progression and metastasis in prostate cancer xenografts and experimental melanomas, respectively. To explore whether the inhibition of FASN could impact oral tongue squamous cell carcinoma (OTSCC) metastatic spread, an orthotopic model was developed by the implantation of SCC-9 ZsGreen LN-1 cells into the tongue of BALB/c nude mice. These cells were isolated through in vivo selection, show a more invasive behavior in vitro than the parental cells, and generate orthotopic tumors that spontaneously metastasize to cervical lymph nodes in 10 to 15 days only. SCC-9 ZsGreen LN-1 cells also exhibit enhanced production of MMP-2, ERBB2, and CDH2. The treatment with orlistat reduced proliferation and migration, promoted apoptosis, and stimulated the secretion of VEGFA165b by SCC-9 ZsGreen LN-1 cells. In vivo, the drug was able to decrease both the volume and proliferation indexes of the tongue orthotopic tumors and, importantly, reduced the number of metastatic cervical lymph nodes by 43%. These results suggest that FASN is a potential molecular target for the chemotherapy of patients with OTSCC. © 2013 AACR.en
dc.description.abstractFatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Converselpt_BR
dc.relation.ispartofMolecular cancer therapeuticspt_BR
dc.relation.ispartofabbreviationMol. cancer ther.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Association for Cancer Researchpt_BR
dc.date.issued2014pt_BR
dc.identifier.citationMolecular Cancer Therapeutics. American Association For Cancer Research Inc., v. 13, n. 3, p. 585 - 595, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume13pt_BR
dc.description.issuenumber3pt_BR
dc.description.issuesupplementpt_BR
dc.description.firstpage585pt_BR
dc.description.lastpage595pt_BR
dc.rightsfechadopt_BR
dc.rightsFechadopt_br
dc.sourceSCOPUSpt_BR
dc.identifier.issn1535-7163pt_BR
dc.identifier.eissn1538-8514pt_BR
dc.identifier.doi10.1158/1535-7163.MCT-12-1136pt_BR
dc.identifier.urlhttps://mct.aacrjournals.org/content/13/3/585pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber2008/57471-7; 2008/55548-2; 2012/25160-8; 2010/51090-1; 2010/52635-1; 2010/50946-0pt_BR
dc.date.available2015-06-25T17:53:09Z
dc.date.available2015-11-26T14:22:00Z-
dc.date.accessioned2015-06-25T17:53:09Z
dc.date.accessioned2015-11-26T14:22:00Z-
dc.description.provenanceMade available in DSpace on 2015-06-25T17:53:09Z (GMT). No. of bitstreams: 1 2-s2.0-84896302527.pdf: 2033914 bytes, checksum: b5fe6145e2f1508b12b5ed22260ec85e (MD5) Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:22:00Z (GMT). No. of bitstreams: 2 2-s2.0-84896302527.pdf: 2033914 bytes, checksum: b5fe6145e2f1508b12b5ed22260ec85e (MD5) 2-s2.0-84896302527.pdf.txt: 53802 bytes, checksum: e61e76abd60a63914dc2565ce612e9cc (MD5) Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/86395
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86395-
dc.identifier.idScopus2-s2.0-84896302527pt_BR
dc.description.referenceDwivedi, R.C., Kazi, R.A., Agrawal, N., Nutting, C.M., Clarke, P.M., Kerawala, C.J., Evaluation of speech outcomes following treatment of oral and pharyngeal cancers (2009) Cancer Treat Rev, 35, pp. 417-424pt_BR
dc.description.referenceWarnakulasuriya, S., Global epidemiology of oral and oropharyngeal cancer (2009) Oral Oncol, 45, pp. 309-316pt_BR
dc.description.referenceJemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M.J., Cancer statistics, 2009 (2009) CA Cancer J Clin, 9, pp. 225-249pt_BR
dc.description.referenceScully, C., Bagan, J., Oral squamous cell carcinoma: Overview of current understanding of aetiopathogenesis and clinical implications (2009) Oral Dis, 15, pp. 388-399pt_BR
dc.description.referenceSano, D., Myers, J.N., Metastasis of squamous cell carcinoma of the oral tongue (2007) Cancer and Metastasis Reviews, 26 (3-4), pp. 645-662. , DOI 10.1007/s10555-007-9082-y, Forty Years of Metastasis Research: A Tribute to Dr. Isaiah J. Fidlerpt_BR
dc.description.referenceLeemans, C.R., Tiwari, R., Nauta, J.J.P., Van Der, W.I., Snow, G.B., Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor (1994) Cancer, 73 (1), pp. 187-190. , DOI 10.1002/1097-0142(19940101)73:1<187::AID-CNCR2pt_BR
dc.description.referenceForastiere, A., Koch, W., Trotti, A., Sidransky, D., Head and neck cancer (2001) N Engl J Med, 345, pp. 1890-1900pt_BR
dc.description.referenceKuriakose, M.A., Trivedi, N.P., Sentinel node biopsy in head and neck squamous cell carcinoma (2009) Curr Opin Otolaryngol Head Neck Surg, 17, pp. 100-110pt_BR
dc.description.referenceVokes, E.E., Weichselbaum, R.R., Lippman, S.M., Hong, W.K., Head and neck cancer (1993) N Engl J Med, 328, pp. 184-194pt_BR
dc.description.referenceClark, J.R., Naranjo, N., Franklin, J.H., De Almeida, J., Gullane, P.J., Established prognostic variables in N0 oral carcinoma (2006) Otolaryngology - Head and Neck Surgery, 135 (5), pp. 748-753. , DOI 10.1016/j.otohns.2006.05.751, PII S0194599806026301pt_BR
dc.description.referenceRusthoven, K., Ballonoff, A., Raben, D., Chen, C., Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma (2008) Cancer, 112, pp. 345-351pt_BR
dc.description.referenceBello, I.O., Soini, Y., Salo, T., Prognostic evaluation of oral tongue cancer: Means, markers and perspectives (I) (2010) Oral Oncol, 46, pp. 630-635pt_BR
dc.description.referencePriante, A.V., Castilho, E.C., Kowalski, L.P., Second primary tumors in patients with head and neck cancer (2011) Curr Oncol Rep, 13, pp. 132-137pt_BR
dc.description.referenceBaron, A., Migita, T., Tang, D., Loda, M., Fatty acid synthase: A metabolic oncogene in prostate cancer? (2004) J Cell Biochem, 91, pp. 47-53pt_BR
dc.description.referenceLiu, H., Liu, J.-Y., Wu, X., Zhang, J.T., Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker (2010) Int J Biochem Mol Biol, 1, pp. 69-89pt_BR
dc.description.referenceKuhajda, F.P., Fatty acid synthase and cancer: New application of an old pathway (2006) Cancer Res, 66, pp. 5977-5980pt_BR
dc.description.referenceAgostini, M., Silva, S.D., Zecchin, K.G., Coletta, R.D., Jorge, J., Loda, M., Graner, E., Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells (2004) Oral Oncology, 40 (7), pp. 728-735. , DOI 10.1016/j.oraloncology.2004.01.011, PII S1368837504000272pt_BR
dc.description.referenceSilva, S.D., Agostini, M., Nishimoto, I.N., Coletta, R.D., Alves, F.A., Lopes, M.A., Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study (2004) Oral Oncol, 40, pp. 688-696pt_BR
dc.description.referenceSilva, S.D., Cunha, I.W., Rangel, A.L., Jorge, J., Zecchin, K.G., Agostini, M., Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes (2008) Virchows Arch, 453, pp. 57-67pt_BR
dc.description.referenceSilva, S.D., Perez, D.E., Nishimoto, I.N., Alves, F.A., Pinto, C.A.L., Kowalski, L.P., Graner, E., Fatty acid synthase expression in squamous cell carcinoma of the tongue: Clinicopathological findings (2008) Oral Diseases, 14 (4), pp. 376-382. , DOI 10.1111/j.1601-0825.2007.01395.xpt_BR
dc.description.referenceDa Silva, S.D., Cunha, I.W., Nishimoto, I.N., Soares, F.A., Carraro, D.M., Kowalski, L.P., Clinicopathological significance of ubiquitin-specific protease 2 (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas (2009) Oral Oncol, 45, pp. e134-e139pt_BR
dc.description.referenceVazquez-Martin, A., Colomer, R., Brunet, J., Lupu, R., Menendez, J.A., Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells (2008) Cell Proliferation, 41 (1), pp. 59-85. , DOI 10.1111/j.1365-2184.2007.00498.xpt_BR
dc.description.referenceMigita, T., Ruiz, S., Fornari, A., Fiorentino, M., Priolo, C., Zadra, G., Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer (2009) J Natl Cancer Inst, 101, pp. 519-532pt_BR
dc.description.referencePizer, E.S., Wood, F.D., Heine, H.S., Romantsev, F.E., Pasternack, G.R., Kuhajda, F.P., Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer (1996) Cancer Research, 56 (6), pp. 1189-1193pt_BR
dc.description.referencePizer, E.S., Chrest, F.J., DiGiuseppe, J.A., Han, W.F., Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines (1998) Cancer Research, 58 (20), pp. 4611-4615pt_BR
dc.description.referenceKridel, S.J., Axelrod, F., Rozenkrantz, N., Smith, J.W., Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity (2004) Cancer Res, 64, pp. 2070-2075pt_BR
dc.description.referenceMenendez, J.A., Vellon, L., Lupu, R., Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3 mediated transcriptional repression of Her2/neu (erbB-2) oncogene (2005) Ann Oncol, 16, pp. 1253-1267pt_BR
dc.description.referenceLiu, H., Liu, Y., Zhang, J.-T., A new mechanism of drug resistance in breast cancer cells: Fatty acid synthase overexpression-mediated palmitate overproduction (2008) Molecular Cancer Therapeutics, 7 (2), pp. 263-270. , http://mct.aacrjournals.org/cgi/reprint/7/2/263, DOI 10.1158/1535-7163.MCT-07-0445pt_BR
dc.description.referenceCarvalho, M.A., Zecchin, K.G., Seguin, F., Bastos, D.C., Agostini, M., Rangel, A.L., Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model (2008) Int J Cancer, 123, pp. 2557-2565pt_BR
dc.description.referenceZecchin, K.G., Alberici, L.C., Riccio, M.F., Eberlin, M.N., Vercesi, A.E., Graner, E., Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells (2011) Rapid Commun Mass Spectrom, 25, pp. 449-452pt_BR
dc.description.referenceZecchin, K.G., Rossato, F.A., Raposo, H.F., Melo, D.R., Alberici, L.C., Oliveira, H.C., Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis (2011) Lab Invest, 91, pp. 232-240pt_BR
dc.description.referenceHarrell, J.C., Dye, W.W., Allred, D.C., Jedlicka, P., Spoelstra, N.S., Sartorius, C.A., Horwitz, K.B., Estrogen receptor positive breast cancer metastasis: Altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes (2006) Cancer Research, 66 (18), pp. 9308-9315. , DOI 10.1158/0008-5472.CAN-06-1769pt_BR
dc.description.referenceRamírez-Zacarías, J.L., Castro-Muñozledo, F., Kuri-Harcuch, W., Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O (1992) Histochemistry, 97, pp. 493-497pt_BR
dc.description.referenceDole, V.P., Meinertz, H., Microdetermination of Long-chain Fatty Acids in Plasma and Tissues (1960) J Biol Chem, 235, pp. 2595-2599pt_BR
dc.description.referenceKnowles, L.M., Axelrod, F., Browne, C.D., Smith, J.W., A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2 (2004) J Biol Chem, 279, pp. 30540-30545pt_BR
dc.description.referenceNurmenniemi, S., Sinikumpu, T., Alahuhta, I., Salo, S., Sutinen, M., Santala, M., A novel organotypic model mimics the tumor microenvironment (2009) Am J Pathol, 175, pp. 1281-1291pt_BR
dc.description.referenceYorioka, C.W., Coletta, R.D., Alves, F., Nishimoto, I.N., Kowalski, L.P., Graner, E., Matrix metalloproteinase-2 and -9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients (2002) Int J Oncol, 20, pp. 189-194pt_BR
dc.description.referenceJohnson, F.B., Lipids (1992) Laboratory Methods in Histotechnology, p. 177. , Prophet EB, Mills B, Arrington JB, Sobin LH, editors. Armed Forces Institute of Pathology. Washington, DCpt_BR
dc.description.referenceDa Silva, S.D., Ferlito, A., Takes, R.P., Brakenhoff, R.H., Valentin, M.D., Woolgar, J.A., Advances and applications of oral cancer basic research (2011) Oral Oncol, 47, pp. 783-791pt_BR
dc.description.referenceMenendez, J.A., Vellon, L., Lupu, R., The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells (2006) Int J Gynecol Cancer, 16, pp. 219-221pt_BR
dc.description.referenceLittle, J.L., Wheeler, F.B., Fels, D.R., Koumenis, C., Kridel, S.J., Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells (2007) Cancer Res, 67, pp. 1262-1269pt_BR
dc.description.referenceDowling, S., Cox, J., Cenedella, R.J., Inhibition of fatty acid synthase by Orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo (2009) Lipids, 44, pp. 489-498pt_BR
dc.description.referenceDeepa, P.R., Vandhana, S., Jayanthi, U., Krishnakumar, S., Therapeutic and toxicological evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells (2012) Basic Clin Pharmacol Toxicol, 110, pp. 494-503pt_BR
dc.description.referenceGelebart, P., Zak, Z., Anand, M., Belch, A., Lai, R., Blockade of Fatty Acid synthase triggers significant apoptosis in mantle cell lymphoma (2012) PLoS ONE, 7, pp. e33738pt_BR
dc.description.referenceMurata, S., Yanagisawa, K., Fukunaga, K., Oda, T., Kobayashi, A., Sasaki, R., Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice (2010) Cancer Sci, 101, pp. 1861-1865pt_BR
dc.description.referenceZaytseva, Y.Y., Rychahou, P.G., Gulhati, P., Elliott, V.A., Mustain, W.C., O'Connor, K., Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer (2012) Cancer Res, 72, pp. 1504-1517pt_BR
dc.description.referenceScott, K.E., Wheeler, F.B., Davis, A.L., Thomas, M.J., Ntambi, J.M., Seals, D.F., Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis (2012) PLoS ONE, 7, pp. e29761pt_BR
dc.description.referenceYoshii, Y., Furukawa, T., Oyama, N., Hasegawa, Y., Kiyono, Y., Nishii, R., Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: Uptake of radiolabeled acetate as a predictor of the targeted therapy outcome (2013) PLoS ONE, 8, pp. e64570pt_BR
dc.description.referenceKuemmerle, N.B., Rysman, E., Lombardo, P.S., Flanagan, A.J., Lipe, B.C., Wells, W.A., Lipoprotein lipase links dietary fat to solid tumor cell proliferation (2011) Mol Cancer Ther, 10, pp. 427-436pt_BR
dc.description.referenceGraner, E., Tang, D., Rossi, S., Baron, A., Migita, T., Weinstein, L.J., Lechpammer, M., Loda, M., The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer (2004) Cancer Cell, 5 (3), pp. 253-261. , DOI 10.1016/S1535-6108(04)00055-8, PII S1535610804000558pt_BR
dc.description.referenceYoshimoto, M., Waki, A., Yonekura, Y., Sadato, N., Murata, T., Omata, N., Takahashi, N., Fujibayashi, Y., Characterization of acetate metabolism in tumor cells in relation to cell proliferation: Acetate metabolism in tumor cells (2001) Nuclear Medicine and Biology, 28 (2), pp. 117-122. , DOI 10.1016/S0969-8051(00)00195-5, PII S0969805100001955pt_BR
dc.description.referenceBrowne, C.D., Hindmarsh, E.J., Smith, J.W., Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor (2006) FASEB Journal, 20 (12), pp. 2027-2035. , http://www.fasebj.org/cgi/reprint/20/12/2027.pdf, DOI 10.1096/fj.05-5404compt_BR
dc.description.referenceSeguin, F., Carvalho, M.A., Bastos, D.C., Agostini, M., Zecchin, K.G., Alvarez-Flores, M.P., The fatty acid synthase (FASN) inhibitor orlistat reduces experimental metastasis and angiogenesis in B16-F10 melanomas (2012) Br J Cancer, 107, pp. 977-987pt_BR
dc.description.referencePatel, V., Marsh, C.A., Dorsam, R.T., Mikelis, C.M., Masedunskas, A., Amornphimoltham, P., Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer (2011) Cancer Res, 71, pp. 7103-7112pt_BR
dc.description.referenceKant, S., Kumar, A., Singh, S.M., Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules (2012) Biochim Biophys Acta, 1820, pp. 1764-1773pt_BR
dc.description.referenceSwinnen, J.V., Van Veldhoven, P.P., Timmermans, L., De Schrijver, E., Brusselmans, K., Vanderhoydonc, F., Van De, S.T., Verhoeven, G., Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains (2003) Biochemical and Biophysical Research Communications, 302 (4), pp. 898-903. , DOI 10.1016/S0006-291X(03)00265-1pt_BR
dc.description.referenceRysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation (2010) Cancer Res, 70, pp. 8117-8126pt_BR
dc.description.referenceVandhana, S., Coral, K., Jayanthi, U., Deepa, P.R., Krishnakumar, S., Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors (2013) Biochim Biophys Acta, 1831, pp. 1458-1466pt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamentopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odpt_BR
dc.identifier.source2-s2.0-84896302527pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0119-6992pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-5285-3046pt_BR
dc.creator.orcid0000-0002-4737-7935pt_BR
dc.type.formArtigopt_BR
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84896302527.pdf1.99 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.