Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/86117
Type: Artigo de periódico
Title: Antinociceptive Activity Of Syzygium Cumini Leaves Ethanol Extract On Orofacial Nociception Protocols In Rodents
Author: Quintans J.S.S.
Brito R.G.
Aquino P.G.V.
Franca P.H.B.
Siqueira-Lima P.S.
Santana A.E.G.
Ribeiro E.A.N.
Salvador M.J.
Araujo-Junior J.X.
Quintans-Junior L.J.
Abstract: Context: Syzygium cumini (L.) Skeels (Myrtaceae) is a tree with dark purple fruits, popularly known as "jambolão" or "jambolan". In folk medicine, this plant is used for the treatment of diabetes and inflammatory conditions. Objective: We investigated the antinociceptive effect of ethanol extract (EE) from S. cumini leaves on orofacial nociception. Material and methods: The antinociceptive effects of the EE obtained from the leaves of S. cumini were evaluated in mice using formalin- and glutamate-induced orofacial nociception. Results: ESI-MS/MS analyses demonstrated that major constituents in the analyzed samples coincided with the mass of the phenolic acids and flavonoids. In pharmacological approach, pre-treatment with EE (100, 200, or 400mg/kg, p.o.) significantly reduced (p<0.05 or p<0.01) the percentage of paw licks time during phase 2 (43.2, 47.1, and 57.4%, respectively) of a formalin pain test when compared to control group animals. This effect was prevented by pretreatment with glibenclamide and NG-nitro-l-arginine (l-NOARG). The extract, all doses, also caused a marked inhibition (p<0.01 or p<0.001) of glutamate-induced orofacial nociception (38.8, 51.7, and 54.7%) when compared with the control group. No effect was observed with the rota-rod model. Conclusions: We can suggest that the antinociceptive effect of the EE is mediated by peripheral mechanisms, possibly involving KATP channels and the nitric oxide pathways. These effects appear to be related to the presence of flavonoids compounds, such as quercetin. © 2014 Informa Healthcare USA, Inc. All rights reserved.
Editor: Informa Healthcare
Rights: fechado
Identifier DOI: 10.3109/13880209.2013.870582
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900802525&partnerID=40&md5=765511052b9f82978da410ee27f7c4b5
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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