Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/85987
Type: Artigo de periódico
Title: Increased Circulating Pedf And Low Sicam-1 Are Associated With Sickle Cell Retinopathy
Author: Cruz P.R.S.
Lira R.P.C.
Pereira Filho S.A.C.
Souza B.B.
Mitsuushi F.N.
Menaa F.
Fertrin K.Y.
Vasconcellos J.P.C.
Conran N.
Costa F.F.
Melo M.B.
Abstract: Sickle cell retinopathy (SCR) develops in up to 30% of sickle cell disease patients (SCD) during the second decade of life. Treatment for this affection remains palliative, so studies on its pathophysiology may contribute to the future development of novel therapies. SCR is more frequently observed in hemoglobin SC disease and derives from vaso-occlusion in the microvasculature of the retina leading to neovascularization and, eventually, to blindness. Circulating inflammatory cytokines, angiogenic factors, and their interaction may contribute to the pathophysiology of this complication. Angiopoietin (Ang)-1, Ang-2, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule (ICAM)-1, E-selectin, P-selectin, IL1-β, TNF-α, pigment epithelium derived factor (PEDF) and vascular endothelial growth factor plasmatic levels were determined in 37 SCD patients with retinopathy, 34 without retinopathy, and healthy controls. We observed that sICAM-1 is significantly decreased, whereas PEDF is elevated in HbSC patients with retinopathy (P = 0.012 and P = 0.031, respectively). Ang-1, Ang-2 and IL1-β levels were elevated in SCD patients (P = 0.001, P < 0.001 and P = 0.001, respectively), compared to controls, and HbSS patients presented higher levels of Ang-2 compared to HbSC (P < 0.001). Our study supports the possible influence of sICAM-1 and PEDF on the pathophysiology of retinal neovascularization in SCD patients. © 2014 Elsevier Inc. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.bcmd.2014.08.003
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84906302345&partnerID=40&md5=04f9fbc8f7777418151869b91b49b812
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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