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dc.typeArtigo de periódicopt_BR
dc.titleOxidative Stress And Susceptibility To Mitochondrial Permeability Transition Precedes The Onset Of Diabetes In Autoimmune Non-obese Diabetic Micept_BR
dc.contributor.authorMalaguti C.pt_BR
dc.contributor.authorLa Guardia P.G.pt_BR
dc.contributor.authorLeite A.C.R.pt_BR
dc.contributor.authorOliveira D.N.pt_BR
dc.contributor.authorDe Lima Zollner R.L.pt_BR
dc.contributor.authorCatharino R.R.pt_BR
dc.contributor.authorVercesi A.E.pt_BR
dc.contributor.authorOliveira H.C.F.pt_BR
unicamp.authorMalaguti, C., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorLa Guardia, P.G., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorLeite, A.C.R., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazil, Biologia Estrutural e Funcional, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorOliveira, D.N., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorDe Lima Zollner, R.L., Clínica Médica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorCatharino, R.R., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorVercesi, A.E., Departamentos de Patologia Clínica, Universidade Estadual de Campinas, SP, Brazilpt_BR
unicamp.authorOliveira, H.C.F., Biologia Estrutural e Funcional, Universidade Estadual de Campinas, SP, Brazilpt_BR
dc.description.abstractBeta cell destruction in type 1 diabetes (TID) is associated with cellular oxidative stress and mitochondrial pathway of cell death. The aim of this study was to determine whether oxidative stress and mitochondrial dysfunction are present in T1D model (non-obese diabetic mouse, NOD) and if they are related to the stages of disease development. NOD mice were studied at three stages: non-diabetic, pre-diabetic, and diabetic and compared with age-matched Balb/c mice. Mitochondria respiration rates measured at phosphorylating and resting states in liver and soleus biopsies and in isolated liver mitochondria were similar in NOD and Balb/c mice at the three disease stages. However, NOD liver mitochondria were more susceptible to calcium-induced mitochondrial permeability transition as determined by cyclosporine-A-sensitive swelling and by decreased calcium retention capacity in all three stages of diabetes development. Mitochondria H2O2 production rate was higher in non-diabetic, but unaltered in pre-diabetic and diabetic NOD mice. The global cell reactive oxygen species (ROS), but not specific mitochondria ROS production, was significantly increased in NOD lymphomononuclear and stem cells in all disease stages. In addition, marked elevated rates of 2′,7′-dichlorodihydrofluorescein (H2DCF) oxidation were observed in pancreatic islets from non-diabetic NOD mice. Using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) and lipidomic approach, we identified oxidized lipid markers in NOD liver mitochondria for each disease stage, most of them being derivatives of diacylglycerols and phospholipids. These results suggest that the cellular oxidative stress precedes the establishment of diabetes and may be the cause of mitochondrial dysfunction that is involved in beta cell death.en
dc.relation.ispartofFree Radical Researchpt_BR
dc.publisherInforma Healthcarept_BR
dc.identifier.citationFree Radical Research. Informa Healthcare, v. 48, n. 12, p. 1494 - 1504, 2014.pt_BR
dc.description.sponsorshipACRL; Association of College and Research Libraries; CAPES; Association of College and Research Librariespt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.provenanceMade available in DSpace on 2015-06-25T17:51:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T15:39:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
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