Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/85926
Type: Artigo de periódico
Title: Gestational Protein Restriction Delays Prostate Morphogenesis In Male Rats
Author: Pinho C.F.
Ribeiro M.A.
Rinaldi J.C.
Felisbino S.L.
Pinheiro P.F.
Domeniconi R.F.
Fochi R.A.
Boer P.A.
Scarano W.R.
Abstract: Maternal malnutrition due to a low-protein diet is associated with functional disorders in adulthood, which may be related to embryonic development failures. The effects of gestational protein restriction on prostate morphogenesis in male offspring were investigated. Pregnant rat dams were divided into normoprotein (NP; fed a normal diet containing 17% protein) and hypoprotein (LP; fed a diet containing 6% protein) groups. On the day of birth (PND1), anogenital distance and bodyweight were measured in male pups. Seven males per experimental group (one male per litter) were killed, and the pelvic urethra was evaluated. LP offspring showed a significant reduction in bodyweight and anogenital distance on PND1. On three-dimensional reconstruction of the prostate, the number of prostatic buds was lower in LP than in NP males. Mesenchymal cells surrounding the buds were androgen-receptor positive, and the quantity and intensity of nucleus immunoreactivity was decreased in LP. The proliferation index was lower in LP than in NP prostatic buds. Immunoreactivity for α-actin in mesenchymal cells and that for epidermal growth factor receptor in epithelial cells was higher in NP than in LP. Our findings demonstrate that maternal protein restriction delays prostatic morphogenesis, probably because of considerable disruption in the epithelium-mesenchyme interaction. © 2014 CSIRO.
Editor: CSIRO
Rights: fechado
Identifier DOI: 10.1071/RD13132
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84907337829&partnerID=40&md5=2fdf17a9421fb7baefc02eb595af2a77
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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