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Type: Artigo de periódico
Title: Protein-coding Genes And Long Noncoding Rnas Are Differentially Expressed In Dasatinib-treated Chronic Myeloid Leukemia Patients With Resistance To Imatinib
Author: Silveira R.A.
Fachel A.A.
Moreira Y.B.
De Souza C.A.
Costa F.F.
Verjovski-Almeida S.
Pagnano K.B.B.
Abstract: Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. Large-scale gene expression was measured with Agilent microarrays covering protein-coding genes and long (>200 nt) noncoding RNAs (lncRNAs). Sets of genes and lncRNAs significantly differentially expressed (>1.5 fold-change; q value ≤10%) were identified. Ingenuity Pathway Analysis pointed to a number of functions, canonical pathways and gene networks that were significantly enriched with differentially expressed genes. In addition to protein-coding genes, lncRNAs have been recently implicated in pathways leading to tumorigenesis. Our data point to new possible regulatory elements involved in dasatinib resistance in CML. © W. S. Maney & Son Ltd 2014.
Rights: fechado
Identifier DOI: 10.1179/1607845413Y.0000000094
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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