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Type: Artigo de periódico
Title: Antiproliferative Activity Of Synthetic Fatty Acid Amides From Renewable Resources
Author: dos Santos D.S.
Piovesan L.A.
D'Oca C.R.M.
Hack C.R.L.
Treptow T.G.M.
Rodrigues M.O.
Vendramini-Costa D.B.
Ruiz A.L.T.G.
de Carvalho J.E.
D'Oca M.G.M.
Abstract: In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.
Editor: Elsevier Ltd
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2014.11.019
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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