Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/85783
Type: Artigo de periódico
Title: Bioguided Identification Of Antifungal And Antiproliferative Compounds From The Brazilian Orchid Miltonia Flavescens Lindl
Author: Porte L.F.
Santin S.M.O.
Chiavelli L.U.R.
Silva C.C.
Faria T.J.
Faria R.T.
Ruiz A.L.T.G.
Carvalho J.E.
Pomini A.M.
Abstract: The Orchidaceae family is appreciated worldwide for the beauty of its flowers, and hundreds of species of this family occur in Brazil. Yet little is known about the potential of orchids for therapeutic application. We have investigated bioactive compounds produced by the South Brazilian orchid Miltonia flavescens Lindl. Bioguided studies with the fungus Cladosporium herbarum allowed the identification of hydrocinnamic acid as the active antifungal compound. In addition, the chloroform fraction exhibited an interesting activity against human cancer cells, and 5,7-dihydroxy-6,4′- dimethoxyflavone isolated from this fraction was found to be active against seven human cancer cell lines, including NCI/ADR-RES ovary sarcoma, with an IC50 value of 2:6 μg/mL. This is the first report on the cytostatic activity of this flavone against human ovary sarcoma. © 2014 Verlag der Zeitschrift für Naturforschung, Tübingen.
Editor: Verlag der Zeitschrift fur Naturforschung
Rights: fechado
Identifier DOI: 10.5560/ZNC.2012-0192
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84901442310&partnerID=40&md5=cd44e4acba552621c91a06668e916cfd
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.