Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/85562
Type: Artigo
Title: Detection of benz[j]aceanthrylene in urban air and evaluation of its genotoxic potential
Author: Lim, Hwanmi
Mattsson, Åse
Jarvis, Ian W. H.
Bergvall, Christoffer
Bottai, Matteo
Morales, Daniel A.
Kummrow, Fábio
Umbuzeiro, Gisela A.
Stenius, Ulla
Westerholm, Roger
Dreij, Kristian
Abstract: Benz[j]aceanthrylene (B[j]A) is a cyclopenta-fused polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects. We have identified B[j]A in air particulate matter (PM) in samples collected in Stockholm, Sweden and in Limeira, Brazil using LC-GC/MS analysis. Determined concentrations ranged between 1.57 and 12.7 and 19.6-30.2 pg/m3 in Stockholm and Limeira, respectively, which was 11-30 times less than benzo[a]pyrene (B[a]P) concentrations. Activation of the DNA damage response was evaluated after exposure to B[j]A in HepG2 cells in comparison to B[a]P. We found that significantly lower concentrations of B[j]A were needed for an effect on cell viability compared to B[a]P, and equimolar exposure resulted in significant more DNA damage with B[j]A. Additionally, levels of γH2AX, pChk1, p53, pp53, and p21 proteins were higher in response to B[j]A than B[a]P. On the basis of dose response induction of pChk1 and γH2AX, B[j]A potency was 12.5- and 33.3-fold higher than B[a]P, respectively. Although B[j]A levels in air were low, including B[j]A in the estimation of excess lifetime cancer risk increased the risk up to 2-fold depending on which potency factor for B[j]A was applied. Together, our results show that B[j]A could be an important contributor to the cancer risk of air PM.
Benz[j]aceanthrylene (B[j]A) is a cyclopenta-fused polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects. We have identified B[j]A in air particulate matter (PM) in samples collected in Stockholm, Sweden and in Limeira, Brazil usi
Subject: Fisiologia
Química atmosférica
Toxicologia
Câncer
Material particulado
Country: Estados Unidos
Editor: American Chemical Society
Citation: Environmental Science And Technology. American Chemical Society, v. 49, n. 5, p. 3101 - 3109, 2015.
Rights: fechado
Fechado
Identifier DOI: 10.1021/es505458g
Address: https://pubs.acs.org/doi/10.1021/es505458g
Date Issue: 2015
Appears in Collections:FT - Artigos e Outros Documentos

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