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dc.typeArtigo de periódicopt_BR
dc.titleSolid Lipid Nanoparticles As Nucleic Acid Delivery System: Properties And Molecular Mechanismspt_BR
dc.contributor.authorDe Jesus M.B.pt_BR
dc.contributor.authorZuhorn I.S.pt_BR
unicamp.authorDe Jesus, M.B., Department of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1Groningen, Netherlands, Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas UNICAMP, Rua Monteiro Lobato no255Campinas, SP, Brazilpt_BR, I.S., Department of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1Groningen, Netherlandspt
dc.description.abstractSolid lipid nanoparticles (SLNs) have been proposed in the 1990s as appropriate drug delivery systems, and ever since they have been applied in a wide variety of cosmetic and pharmaceutical applications. In addition, SLNs are considered suitable alternatives as carriers in gene delivery. Although important advances have been made in this particular field, fundamental knowledge of the underlying mechanisms of SLN-mediated gene delivery is conspicuously lacking, an imperative requirement in efforts aimed at further improving their efficiency. Here, we address recent advances in the use of SLNs as platform for delivery of nucleic acids as therapeutic agents. In addition, we will discuss available technology for conveniently producing SLNs. In particular, we will focus on underlying molecular mechanisms by which SLNs and nucleic acids assemble into complexes and how the nucleic acid cargo may be released intracellularly. In discussing underlying mechanisms, we will, when appropriate, refer to analogous studies carried out with systems based on cationic lipids and polymers, that have proven useful in the assessment of structure-function relationships. Finally, we will give suggestions for improving SLN-based gene delivery systems, by pointing to alternative methods for SLNplex assembly, focusing on the realization of a sustained nucleic acid release.en
dc.relation.ispartofJournal of Controlled Releasept_BR
dc.identifier.citationJournal Of Controlled Release. Elsevier, v. 201, n. , p. 1 - 13, 2015.pt_BR
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