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Type: Artigo de periódico
Title: Clinical Influence Of Different Intracanal Medications On Th1-type And Th2-type Cytokine Responses In Apical Periodontitis
Author: Martinho F.C.
Nascimento G.G.
Leite F.R.M.
Gomes A.P.M.
Freitas L.F.
Camoes I.C.G.
Abstract: Introduction This clinical study assessed the influence of different intracanal medications on Th1-type and Th2-type cytokine responses in apical periodontitis and monitored the levels of bacteria from primarily infection during endodontic procedures. Methods Thirty primarily infected teeth were randomly divided into 3 groups according to the medication selected: chlorhexidine (CHX), 2% CHX gel; Ca(OH)2/SSL, Ca(OH)2 + SSL; and Ca(OH)2/CHX, Ca(OH)2 + 2% CHX gel (all, n = 10). Bacterial sample was collected from root canals, and the interstitial fluid was sampled from lesions. Culture techniques were used to determine bacterial counts (colony-forming units/mL). Th1 (tumor necrosis factor-α, interferon-γ, and interleukin [IL]-2) and Th2 cytokines (IL-4, IL-5, and IL-13) were measured by enzyme-linked immunosorbent assay. Results All intracanal medication protocols were effective in reducing the bacterial load from root canals (all P <.05) and lowering the levels of Th1-type cytokines in apical lesions (all P <.05), with no differences between them (P >.05). Both Ca(OH)2 treatment protocols significantly increased the levels of Th2-type cytokines (P <.05), with no differences between them (P >.05). Thus, chlorhexidine medication showed the lowest effectiveness in increasing the levels of Th2-type cytokine. After treatment, regardless of the type of medication, the linear regression analysis indicated the down-regulation of Th2-type cytokines by Th1-type cytokines. Conclusions All intracanal medication protocols were effective in reducing bacterial load and lowering the levels of Th1-type cytokines. Thus, the use of Ca(OH)2 medications contributed to the increase in the Th2-type cytokine response in apical periodontitis.
Editor: Elsevier Inc.
Rights: fechado
Identifier DOI: 10.1016/j.joen.2014.09.028
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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