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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.type.categoryoriginal articlept_BR
dc.type.versionpublishedVersionpt_BR
dc.titleInteractions of polymorphisms in different clock genes associated with circadian phenotypes in humanspt_BR
dc.contributor.authorPEDRAZZOLI, Mariopt_BR
dc.contributor.authorSECOLIN, Rodrigopt_BR
dc.contributor.authorESTEVES, Luiz Otávio Bastospt_BR
dc.contributor.authorPEREIRA, Danyella Silvapt_BR
dc.contributor.authorKOIKE, Bruna Del Vechiopt_BR
dc.contributor.authorLOUZADA, Fernando Mazzilipt_BR
dc.contributor.authorLOPES-CENDES, Isciapt_BR
dc.contributor.authorTUFIK, Sergiopt_BR
unicamp.authorLOPES-CENDES, Iscia:Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Genética Médicapt_BR
unicamp.author.externalESTEVES, Luiz Otávio Bastospt
unicamp.author.externalPEREIRA, Danyella Silvapt
unicamp.author.externalKOIKE, Bruna Del Vechiopt
unicamp.author.externalLOUZADA, Fernando Mazzilipt
unicamp.author.externalTUFIK, Sergiopt
unicamp.author.externalSECOLIN, Rodrigopt
unicamp.author.externalPEDRAZZOLI, Mariopt
dc.subjectClock genespt_BR
dc.subjectGene interactionpt_BR
dc.subjectMorningness-eveningnesspt_BR
dc.subjectSleeppt_BR
dc.subjectCircadian rhythmpt_BR
dc.description.abstractSeveral studies have shown that mutations and polymorphisms in clock genes are associated with abnormal circadian parameters in humans and also with more subtle non-pathological phenotypes like chronotypes. However, there have been conflicting results, and none of these studies analyzed the combined effects of more than one clock gene. Up to date, association studies in humans have focused on the analysis of only one clock gene per study. Since these genes encode proteins that physically interact with each other, combinations of polymorphisms in different clock genes could have a synergistic or an inhibitory effect upon circadian phenotypes. In the present study, we analyzed the combined effects of four polymorphisms in four clock genes (Per2, Per3, Clock and Bmal1) in people with extreme diurnal preferences (morning or evening). We found that a specific combination of polymorphisms in these genes is more frequent in people who have a morning preference for activity and there is a different combination in individuals with an evening preference for activity. Taken together, these results show that it is possible to detect clock gene interactions associated with human circadian phenotypes and bring an innovative idea of building a clock gene variation map that may be applied to human circadian biology.en
dc.relation.ispartofGenetics and Molecular Biologypt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSociedade Brasileira de Genéticapt_BR
dc.date.issued2010pt_BR
dc.identifier.citationGenetics and Molecular Biology, v.33, n.4, p.627-632, 2010pt_BR
dc.language.isoengpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage627pt_BR
dc.description.lastpage632pt_BR
dc.rightsabertopt_BR
dc.rights.holderCopyright Sociedade Brasileira de Genéticapt_BR
dc.sourceSciELOpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.doi10.1590/S1415-47572010005000092pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400005pt_BR
dc.identifier.urlhttp://www.scielo.br/pdf/gmb/v33n4/2009-403.pdfpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorremissiveCNPq_Brasilpt_BR
dc.description.sponsorremissiveFAPESP_Brasilpt_BR
dc.description.sponsorremissiveCAPES_Brasilpt_BR
dc.date.available2013-07-26T17:58:39Z
dc.date.available2016-07-01T15:12:19Z-
dc.date.accessioned2013-07-26T17:58:39Z
dc.date.accessioned2016-07-01T15:12:19Z-
dc.description.provenanceMade available in DSpace on 2013-07-26T17:58:39Z (GMT). No. of bitstreams: 2 art_PEDRAZZOLI_Interactions_of_polymorphisms_in_different_clock_genes_2010.pdf.txt: 25955 bytes, checksum: a66cfffa0533812ea5342fbd7318b088 (MD5) art_PEDRAZZOLI_Interactions_of_polymorphisms_in_different_clock_genes_2010.pdf: 107417 bytes, checksum: 168e681c7ef144b011a2fac170b6ecdc (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2016-07-01T15:12:19Z (GMT). No. of bitstreams: 2 art_PEDRAZZOLI_Interactions_of_polymorphisms_in_different_clock_genes_2010.pdf.txt: 25955 bytes, checksum: a66cfffa0533812ea5342fbd7318b088 (MD5) art_PEDRAZZOLI_Interactions_of_polymorphisms_in_different_clock_genes_2010.pdf: 107417 bytes, checksum: 168e681c7ef144b011a2fac170b6ecdc (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/828
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/828-
dc.contributor.departmentMedicina Genética
dc.contributor.unidadeFCMpt
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