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Type: Artigo de periódico
Title: Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli
Title Alternative: QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli
Author: Volpe, P. L. O.
Montanari, C. A.
Abstract: QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log Po/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship.
Subject: biological microcalorimetry
biological response
homologous series
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 20, n. 2, p. 125-131, 1997.
Rights: aberto
Identifier DOI: 10.1590/S0100-40421997000200002
Date Issue: 1-Apr-1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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