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Type: Artigo de periódico
Title: Modeling the ATP Production in Mitochondria
Author: Saa, A
Siqueira, KM
Abstract: We revisit here the mathematical model for ATP production in mitochondria introduced recently by Bertram, Pedersen, Luciani, and Sherman (BPLS) as a simplification of the more complete but intricate Magnus and Keizer's model. We identify some inaccuracies in the BPLS original approximations for two flux rates, namely the adenine nucleotide translocator rate J (ANT) and the calcium uniporter rate J (uni). We introduce new approximations for such flux rates and then analyze some of the dynamical properties of the model. We infer, from exhaustive numerical explorations, that the enhanced BPLS equations have a unique attractor fixed point for physiologically acceptable ranges of mitochondrial variables and respiration inputs, as one would indeed expect from homeostasis. We determine, in the stationary regime, the dependence of the mitochondrial variables on the respiration inputs, namely the cytosolic concentration of calcium Ca-c and the substrate fructose 1,6-bisphosphate FBP. The same dynamical effects of calcium and FBP saturations reported for the original BPLS model are observed here. We find out, however, a novel nonstationary effect, which could be, in principle, physiologically interesting: some response times of the model tend to increase considerably for high concentrations of calcium and/or FBP. In particular, the larger the concentrations of Ca-c and/or FBP, the larger the necessary time to attain homeostasis.
Subject: Mitochondria
Mathematical model
Country: EUA
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s11538-013-9862-1
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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