Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/82301
Type: Artigo de periódico
Title: Modeling of ion exchange expanded-bed chromatography for the purification of C-phycocyanin
Author: Moraes, CC
Mazutti, MA
Maugeri, F
Kalil, SJ
Abstract: This work is focused on the experimental evaluation and mathematical modeling of ion exchange expanded-bed chromatography for the purification of C-phycocyanin from crude fermentative broth containing Spirulina platensis cells. Experiments were carried out in different expansion degree to evaluate the process performance. The experimental breakthrough curves were used to estimate the mass transfer and kinetics parameters of the proposed model, using the Particle Swarm Optimization algorithm (PSO). The proposed model satisfactorily fitted the experimental data. The results from the model application pointed out that the increase in the initial bed height does not influence the process efficiency, however enables the operation of expanded-bed column at high volumetric flow rates, improving the productivity. It was also shown that the use of mathematical modeling was a good and promising tool for the optimization of chromatographic processes. (C) 2013 Elsevier B.V. All rights reserved.
Subject: C-phycocyanin
Adsorption
Expanded-bed
Modeling
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.chroma.2013.01.081
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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