Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/82255
Type: Artigo de periódico
Title: MORPHOMETRIC INVESTIGATIONS OF THE COLON MUCOSA IN CHRONIC TRYPANOSOMA-CRUZI INFECTED-RATS
Author: FERNANDES, MIM
ZUCOLOTO, S
COLLARES, EF
FILHO, FF
Abstract: The objective of this investigation was to study the morphometry of the epithelial mucosa in the chronic phase of T. cruzi infection. Nine young female Wistar rats were inoculated with T. cruzi. Ten months after inoculation the animals were sacrificed and the proximal colon was collected for morphometric measurements of the thickness of the muscle layers, the number of neurons in the myenteric plexus, the crypt cell population (CCP), crypt cell production per crypt (CCPC) and turnover time (TT) of the epithelium. There was no muscle layer hypertrophy but there was significant denervation in the group inoculated with T. cruzi, which also showed hyperplasia of the epithelium. The data suggest that denervation of the myenteric plexus did not induce hypertrophy of the propria muscle layer itself but altered the morphometry of the colonic epithelium in T. cruzi-infected animals, with increased development of CCP and TT. It is possible that this epithelial hyperplasia, as a consequence of a longer crypt cell TT, increased the absorption and secretion activities of the colon, which in turn may participate in the genesis of the enteromegalies observed in the chronic phase of Chagas' Disease.
Subject: CHAGAS DISEASE
EPITHELIAL MORPHOLOGICAL
COLON-CHRONIC PHASE
DENERVATION OF THE MYENTERIC PLEXUS
Editor: Springer Verlag
Rights: fechado
Identifier DOI: 10.1007/BF02899536
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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