Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/82168
Type: Artigo de periódico
Title: Multinuclear magnetic resonance and theoretical calculations in the study of structure and tautomerism of some 2-amino-N '-(aryl)-benzamidines
Author: Suwinski, J
Szczepankiewicz, W
Basso, EA
Tormena, CF
Freitas, MP
Rittner, R
Abstract: H-1, C-13 and N-15 NMR spectra of eight 2-amino-N'-(aryl)-benzamidines and of the parent compound were recorded, and unequivocal chemical shift assignments through the use of COSY, H-1-J resolved, HETCOR and COLOC sequences were performed. H-1 and C-13 chemical shifts for the nuclei of the benzamidine aromatic ring were not affected by the substituents present at N'-phenyl group, while the substituent effects in the chemical shifts of the same nuclei of N'-phenyl ring were very similar to the ones reported for the corresponding monosubstituted benzenes, indicating that there is no interaction between the two aromatic rings. N-15 NMR spectra (DEPT sequence) show just two hydrogenated nitrogen atoms, which confirm that the amino form is the most stable tautomer, but the observation of a sharp signal and two broad signals (N-15 decoupled spectra), and the corresponding broad signal for the =C-NH2 protons (in the H-1 spectra), indicates the occurrence of tautomerism between the amino and imino forms, observable for some of the studied benzamidines. Theoretical calculations lead to the conclusion that these compounds occur mostly as the amino tautomer with Z configuration, which is stabilized by hydrogen bonding. (C) 2003 Elsevier Science B.V. All rights reserved.
Subject: NMR
H-1
C-13
N-15
N '-arylbenzamidines
tautomerism
configuration
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/S1386-1425(03)00124-0
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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