Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/82097
Type: Artigo de periódico
Title: MOUSE-LIVER MICROSOMES (MLM) PROTECT ERYTHROCYTES AGAINST TRIFLUOPERAZINE (TFP) INDUCED AND MECHANICAL HEMOLYSIS WHICH ARE DUE TO TFP MICROSOMAL TRANSFORMATION AND TO THE ACTION OF AN UNIDENTIFIED WATER-SOLUBLE MICROSOMAL FACTOR (UF)
Author: MEIRELLES, NC
MALHEIROS, SVP
RUGGIERO, AC
DEGTEREV, IA
Abstract: Trifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.
Subject: MOUSE LIVER MICROSOMES (MLM) ERYTHROCYTES
TRIFLUOPERAZINE (TFP)
HEMOLYSIS
MICROSOMAL TRANSFORMATION
UNIDENTIFIED WATER-SOLUBLE MICROSOMAL FACTOR (UF)
Country: Suíça
Editor: Medecine Et Hygiene
Rights: fechado
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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