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Type: Artigo de periódico
Title: Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98
Author: de Melo, EB
Martins, JPA
Jorge, TCM
Friozi, MC
Ferreira, MMC
Abstract: A quantitative structure activity relationship (QSAR) study of twenty flavonoid derivatives with antimutagenic activity against 3-nitrofluoranthene (3-NFA) was performed by Partial Least Squares (PLS), using Ordered Predictors Selection (OPS) algorithm for variable selection. Four descriptors (PJI2, Mor27m, G1e and R4u divided by) were selected and a good model (n = 19; R(2) = 0.747; SEC = 0.332, PRESS(cal) = 1.768, F((2.27)) = 23.585; Q(LOO)(2) = 0.590; SEV = 0.388; PRESS(val) = 2 858; R(pred)(2) = 0.591; SEP = 0.394; ARE(pred) = 5.230%, k = 1.005; k' = 0.990; vertical bar R(0)(2) -R(0)'(2)vertical bar = 0 109) was built with two latent variables describing 83 410% of the original information. Leave-N-out cross validation (LNO) and y-randomization were performed in order to confirm the robustness of the model The topological descriptors selected indicate that the antimutagenic activity against 3-NFA depends on molecular size, shape and Sanderson electronegativity of flavonoids. The proposed model may provide a better understanding of the antimutagenic activity of flavonoids and can be used as a guidance for proposition of new chemopreventive agents. (C) 2010 Elsevier Masson SAS All rights reserved.
Subject: QSAR
Model validation
Country: França
Editor: Elsevier France-editions Scientifiques Medicales Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2010.07.017
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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