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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNitric oxide and TNF alpha effects in experimental autoimmune encephalomyelitis demyelinationpt_BR
dc.contributor.authorFarias, ASpt_BR
dc.contributor.authorde la Hoz, Cpt_BR
dc.contributor.authorCastro, FRpt_BR
dc.contributor.authorOliveira, ECpt_BR
dc.contributor.authordos Reis, JRRpt_BR
dc.contributor.authorSilva, JSpt_BR
dc.contributor.authorLangone, Fpt_BR
dc.contributor.authorSantos, LMBpt_BR
unicamp.author.emailleonilda@unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Inst Biol, Dept Microbiol & Immunol, Neuroimmunol Unit, BR-13089970 Campinas, SP, Brazil Univ Estadual Campinas, Dept Physiol, BR-13089970 Campinas, SP, Brazil Univ Sao Paulo, Dept Immunol, BR-14049 Ribeirao Preto, Brazilpt_BR
dc.subjectencephalomyelitispt_BR
dc.subjectmacrophage activationpt_BR
dc.subjectnitric oxidept_BR
dc.subject.wosTumor-necrosis-factorpt_BR
dc.subject.wosExperimental Allergic Encephalomyelitispt_BR
dc.subject.wosMyelin Oligodendrocyte Glycoproteinpt_BR
dc.subject.wosCentral-nervous-systempt_BR
dc.subject.wosMultiple-sclerosispt_BR
dc.subject.wosProteolipid Proteinpt_BR
dc.subject.wosSjl/j Micept_BR
dc.subject.wosSynthasept_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosInductionpt_BR
dc.description.abstractThe involvement of inducible nitric oxide synthase ( iNOS), which plays various roles in the progression of autoimmune diseases, was studied in iNOS knockout ( KO) mice and wildtype (WT) controls with respect to experimental autoimmune encephalomyelitis (EAE). The iNOS ( KO) mice presented a less severe form of the disease than the WT control mice. Although the levels of TNF alpha decreased in the periphery in both groups, an increase in the number of TNF alpha-positive cells was detected in the central nervous system during the acute phase of EAE in the WT mice, but not in the KO mice. These findings suggest that NO and TNF alpha contribute to the pathogenesis of acute EAE. Copyright (C) 2007 S. Karger AG, Basel.pt
dc.relation.ispartofNeuroimmunomodulationpt_BR
dc.relation.ispartofabbreviationNeuroimmunomodulationpt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherKargerpt_BR
dc.date.issued2007pt_BR
dc.identifier.citationNeuroimmunomodulation. Karger, v. 14, n. 1, n. 32, n. 38, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume14pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage32pt_BR
dc.description.lastpage38pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.karger.com/Services/RightsPermissionspt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1021-7401pt_BR
dc.identifier.wosidWOS:000249203400006pt_BR
dc.identifier.doi10.1159/000107286pt_BR
dc.date.available2014-11-15T00:30:03Z
dc.date.available2015-11-26T16:09:11Z-
dc.date.accessioned2014-11-15T00:30:03Z
dc.date.accessioned2015-11-26T16:09:11Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T00:30:03Z (GMT). No. of bitstreams: 1 WOS000249203400006.pdf: 180495 bytes, checksum: 8a96155a3150c5025f4e6e28e6a277a1 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:09:11Z (GMT). No. of bitstreams: 2 WOS000249203400006.pdf: 180495 bytes, checksum: 8a96155a3150c5025f4e6e28e6a277a1 (MD5) WOS000249203400006.pdf.txt: 31832 bytes, checksum: 20174c66027c87d201c17dc0332a678a (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81987pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/81987
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81987-
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