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Type: Artigo de periódico
Title: Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
Author: Gomes, PC
de Souza, BM
Dias, NB
Cesar-Tognoli, LMM
Silva, LC
Tormena, CF
Rittner, R
Richardson, M
Cordeiro, MN
Palma, MS
Abstract: Nigriventrine was isolated from the 'armed' spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.
Subject: Spider venom
Low molecular mass
Glutamate receptor
Natural product
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2010.11.021
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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