Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81907
Type: Artigo de periódico
Title: Mutation analysis of the HFE gene in Brazilian populations
Author: Agostinho, MF
Arruda, VR
Basseres, DS
Bordin, S
Soares, MCP
Menezes, RC
Costa, FF
Saad, STO
Abstract: We analyzed the frequency of the C282Y and H63D mutations in the HFE gene in 227 individuals from Brazil comprising 71 Caucasians, 91 racially mixed Caucasian African-derived Amerindians (both populations from Southeast Brazil), 85 African-derived subjects (from Northeast Brazil) and 75 Parakana Indians, Allelic frequency of the mutation C. 845G6A (C282Y) was 1.4% in the Caucasian population, 1.1% in the African-derived population, 1.1% in the racially mixed normal controls and 0% in the Parakana Indians. In the African-derived population, the C282Y mutation was present on chromosomes bearing the haplotype 6/1h according to Beutler and West (1997). Allelic frequency of the mutation C. 187C6G (H63D) was 16.3% in the Caucasian population, 7.5% in the African-derived population, 9.8% in the racially mixed controls and 0% in the Amerindians. The presence of these mutations in the African-derived population reflects the fact that these subjects may have undergone a non-identified racial admixture in their past history. The absence of both defects in the Amerindians suggests that these mutations have emerged after the migration of Polynesians to America, or that they may not have reached the Polynesian population until after the migration to America had occurred.
Subject: hemochromatosis
HFE gene
Brazilian population
Amerindians
Parakana Indians
Country: EUA
Editor: Academic Press Inc
Rights: fechado
Identifier DOI: 10.1006/bcmd.1999.0260
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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