Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81900
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGroppo, Francisco Carlospt_BR
dc.typeArtigopt_BR
dc.titleMutagenicity induced by the hydroalcoholic extract of the medicinal plant Plathymenia reticulata Benthpt_BR
dc.contributor.authorDella Torre, A.pt_BR
dc.contributor.authorAlbuquerque, L. B. L.pt_BR
dc.contributor.authorFarrapo, N. M.pt_BR
dc.contributor.authorOshima-Franco, Y.pt_BR
dc.contributor.authorSantos, M. G.pt_BR
dc.contributor.authorTavares, R. V. S.pt_BR
dc.contributor.authorRodas, A. C. D.pt_BR
dc.contributor.authorDal Belo, C. A.pt_BR
dc.contributor.authorCardoso, C. R. P.pt_BR
dc.contributor.authorVaranda, E. A.pt_BR
dc.contributor.authorGroppo, F. C.pt_BR
dc.contributor.authorLopes, P. S.pt_BR
dc.subjectTestes de mutagenicidadept_BR
dc.subjectExtratos vegetaispt_BR
dc.subject.otherlanguagePlant extractspt_BR
dc.subject.otherlanguageMutagenicity testingpt_BR
dc.description.abstractPlathymenia reticulata Benth has an anti-inflammatory effect and is capable of neutralizing the neuromuscular blockade induced by Bothrops jararacussu or Crotalus durissus terrificus venoms, probably by precipitating venom proteins (an effect caused by plant tannins). The present study aimed to evaluate the mutagenic activity of P. reticulata by using the Salmonella mutagenicity assay (Ames test) and the micronucleus test in CHO-K1 cells. P. reticulata extract concentrations of 2.84, 5.68, 11.37, and 19.90 mg/plate were assayed by the Ames test using TA97a, TA98, TA100 and TA102 bacterial strains, with (+S9) and without (-S9) metabolic activation. Concentrations of 5, 1.6 and 0.5 mu g/mL of P. reticulata extract were used for the micronucleus test. P. reticulata extract was mutagenic to TA98 (-S9) and showed signs of mutagenic activity in TA97a and TA102 (both -S9) strains. Micronucleus test CBPI values showed that the endogenous metabolic system increased the number of viable cells when compared to the non-activated samples and the micronucleus frequency increased when the cells were treated in the absence of S9. We concluded that P. reticulata extract may present direct mutagenic propertiespt
dc.relation.ispartofJournal of venomous animals and toxins including tropical diseasespt_BR
dc.relation.ispartofabbreviationJ. venom. anim. toxins incl. trop. dis.pt_BR
dc.publisher.cityBotucatu, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherUNESP/Centro de Estudos de Venenos e Animais Peçonhentospt_BR
dc.date.issued2011pt_BR
dc.identifier.citationJournal Of Venomous Animals And Toxins Including Tropical Diseases. Cevap-unesp, v. 17, n. 2, n. 190, n. 198, 2011.pt_BR
dc.language.isoengpt_BR
dc.description.volume17pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage190pt_BR
dc.description.lastpage198pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.eissn1678-9199pt_BR
dc.identifier.doi10.1590/S1678-91992011000200010 pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200010pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-08-01T18:39:31Z
dc.date.available2015-11-26T17:06:29Z-
dc.date.accessioned2014-08-01T18:39:31Z
dc.date.accessioned2015-11-26T17:06:29Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:39:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2011 Bitstreams deleted on 2020-05-14T20:38:26Z: WOS000290866500010.pdf,. Added 1 bitstream(s) on 2020-05-14T20:42:41Z : No. of bitstreams: 2 000290866500010.pdf: 480562 bytes, checksum: 9550eaa050c4ecee7c415154914987cc (MD5) WOS000290866500010.pdf.txt: 35652 bytes, checksum: de29bcbc6b2f36de0e3418fac6302c81 (MD5) Bitstreams deleted on 2020-06-05T14:31:36Z: 000290866500010.pdf,. Added 1 bitstream(s) on 2020-06-05T14:34:17Z : No. of bitstreams: 2 000290866500010.pdf: 480562 bytes, checksum: 9550eaa050c4ecee7c415154914987cc (MD5) WOS000290866500010.pdf.txt: 35652 bytes, checksum: de29bcbc6b2f36de0e3418fac6302c81 (MD5) Bitstreams deleted on 2020-06-30T18:46:47Z: 000290866500010.pdf,. Added 1 bitstream(s) on 2020-06-30T18:49:27Z : No. of bitstreams: 2 000290866500010.pdf: 312378 bytes, checksum: b126ef8f6bc4bace18d7c5b74cbe93d8 (MD5) WOS000290866500010.pdf.txt: 35652 bytes, checksum: de29bcbc6b2f36de0e3418fac6302c81 (MD5)en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:06:29Z (GMT). No. of bitstreams: 2 WOS000290866500010.pdf: 332676 bytes, checksum: 78bcf09cdcdb5649b415159b5544eb3e (MD5) WOS000290866500010.pdf.txt: 35652 bytes, checksum: de29bcbc6b2f36de0e3418fac6302c81 (MD5) Previous issue date: 2011en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81900
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81900-
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordMicronucleus testpt_BR
dc.subject.keywordPlathymenia reticulatapt_BR
dc.subject.keywordAmes testpt_BR
dc.identifier.source000290866500010-
dc.creator.orcid0000-0002-8513-773Xpt_BR
dc.type.formArtigopt_BR
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