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Type: Artigo de periódico
Title: Optimization of N, N, N-trimethylchitosan synthesis by factorial design
Author: de Britto, D
Frederico, FR
Assis, OBG
Abstract: Factorial design analysis was applied to optimize the synthesis, via a new route, of N, N, N-trimethylchitosan, based on dimethylsulfate as a methylating agent. The responses analyzed were weight yield, solubility and average degree of quaternization. Temperature was verified as the most important variable, as it caused the most variation in the response. X(T) = -54.52,-9.50 and -7.25, respectively, for weight yield, solubility and degree of quaternization. A sharp decrease in the viscosimetric and gel permeation chromatography parameters proved that severe depolymerization took place at high reaction temperatures. Contact angle measurements showed a decrease in the hydrophilic character of over-methylated samples. (C) 2011 Society of Chemical Industry
Subject: optimization
factorial design
N, N, N-trimethylchitosan
molecular weight
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/pi.3038
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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