Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81606
Type: Artigo de periódico
Title: OPTIMAL CHEMOTHERAPY - A CASE-STUDY WITH DRUG-RESISTANCE, SATURATION EFFECT, AND TOXICITY
Author: COSTA, MIS
BOLDRINI, JL
BASSANEZI, RC
Abstract: A system of differential equations for the control of tumour cell growth in a cycle-nonspecific chemotherapy is presented. A rate-of-kill term of saturation type, drug resistance, and toxicity are taken into account in a class of optimal control problems. Some results are obtained for general tumour cell growth rates. A detailed analysis is presented for the Malthusian cell growth, which shows a variety of optimal treatments according to the values of the model parameters and initial tumour level.
Subject: OPTIMAL CONTROL
SATURATION EFFECT
DRUG RESISTANCE
TOXICITY
CANCER CHEMOTHERAPY
Country: Inglaterra
Editor: Oxford Univ Press United Kingdom
Rights: fechado
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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