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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatmentpt_BR
dc.contributor.authorGobbo, MGpt_BR
dc.contributor.authorRibeiro, DLpt_BR
dc.contributor.authorTaboga, SRpt_BR
dc.contributor.authorde Almeida, EApt_BR
dc.contributor.authorGoes, RMpt_BR
unicamp.author.emailremagoes@ibilce.unesp.brpt_BR
unicamp.authorGobbo, Marina Guimaraes Univ Estadual Campinas, Inst Biol, Dept Cell Biol, Campinas, SP, Brazilpt_BR
unicamp.authorGobbo, Marina Guimaraes Taboga, Sebastiao Roberto Goes, Rejane Maira Univ Estadual Paulisto UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Sao Paulo, Brazilpt_BR
unicamp.authorRibeiro, Daniele Lisboa Fed Univ Uberlandia UFU, Inst Biomed Sci, Histol Sect, Uberlandia, MG, Brazilpt_BR
unicamp.authorde Almeida, Eduardo Alves Univ Estadual Paulista UNESP, Inst Biosci Languages & Exact Sci, Dept Chem & Environm Sci, Sao Paulo, Brazilpt_BR
dc.subjectEXPERIMENTAL DIABETESpt_BR
dc.subjectOXIDATIVE STRESSpt_BR
dc.subjectPROSTATEpt_BR
dc.subjectVITAMIN C SUPPLEMENTATIONpt_BR
dc.subjectAPOPTOSISpt_BR
dc.subject.wosProliferative Inflammatory Atrophypt_BR
dc.subject.wosAntioxidant Enzymespt_BR
dc.subject.wosLipid-peroxidationpt_BR
dc.subject.wosCellspt_BR
dc.subject.wosEpitheliumpt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosInductionpt_BR
dc.subject.wosDamagept_BR
dc.subject.wosCarcinogenesispt_BR
dc.description.abstractNegative consequences of diabetes on the prostate such as involution are associated with diminished testosterone, insulin deficiency, and hyperglycemia. The contributions of oxidative damage, which usually increases with diabetes, are unknown for these alterations. This study evaluated the impact of streptozotocin-induced diabetes on the biomarkers of the antioxidant system of rat ventral prostate, the influence of vitamin C supplementation on these biomarkers, and on the balance between cell proliferation and death. Diabetes (D) was induced in Wistar male rats by streptozotocin (5?mg/100?g b.w., i.p.). Control animals (C) were injected with a vehicle. Vitamin C (150?mg/kg b.w./day) supplementation was introduced by gavage in diabetes (D?+?V) as well as control (C?+?V) groups. Thirty days after diabetes onset, the rats were killed and the ventral prostates were analyzed using light microscopy, immunocytochemistry, and biochemical assays for biomarkers of oxidative stress. In comparison to control groups, the levels of circulating testosterone, proliferating, and androgen receptor-positive cells decreased in diabetic groups regardless of vitamin C treatment whereas apoptosis was increased. The levels of superoxide dismutase and glutathione peroxidase did not change, but the levels of glutathione-S-transferase (GST) were increased in diabetic prostate. Vitamin C supplementation normalized GST activity and recovered the apoptotic rates in the prostate. In conclusion, GST is a good indicator of compensatory oxidant defense in the prostate at earlier stages of diabetes and vitamin C improves its activity and attenuates apoptosis in the gland. J. Cell. Biochem. 113: 22232233, 2012. (c) 2012 Wiley Periodicals, Inc.pt
dc.relation.ispartofJournal Of Cellular Biochemistrypt_BR
dc.relation.ispartofabbreviationJ. Cell. Biochem.pt_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationJournal Of Cellular Biochemistry. Wiley-blackwell, v. 113, n. 7, n. 2223, n. 2233, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume113pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpage2223pt_BR
dc.description.lastpage2233pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0730-2312pt_BR
dc.identifier.wosidWOS:000303797600007pt_BR
dc.identifier.doi10.1002/jcb.24092pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship[302693/2008-4]pt_BR
dc.description.sponsorship[2008/00542-0]pt_BR
dc.description.sponsorship[2009/05078-2]pt_BR
dc.description.sponsorship[2009/06885-9]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2006/03873-1, 2008/05341-2]pt
dc.description.sponsordocumentnumber[302693/2008-4]pt
dc.description.sponsordocumentnumber[2008/00542-0]pt
dc.description.sponsordocumentnumber[2009/05078-2]pt
dc.description.sponsordocumentnumber[2009/06885-9]pt
dc.date.available2014-08-01T18:37:09Z
dc.date.available2015-11-26T17:08:31Z-
dc.date.accessioned2014-08-01T18:37:09Z
dc.date.accessioned2015-11-26T17:08:31Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:37:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:08:31Z (GMT). No. of bitstreams: 2 WOS000303797600007.pdf: 501907 bytes, checksum: 61df23c90d45df5595ffde064c9d2ce3 (MD5) WOS000303797600007.pdf.txt: 45907 bytes, checksum: 9225f45bb5922c170fe5f8c6aa22d231 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81591
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81591-
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