Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81578
Type: Artigo de periódico
Title: OXIDATIVE DAMAGE OF MITOCHONDRIA INDUCED BY FE(II)CITRATE OR T-BUTYL HYDROPEROXIDE IN THE PRESENCE OF CA2+ - EFFECT OF COENZYME-Q REDOX STATE
Author: CASTILHO, RF
KOWALTOWSKI, AJ
MEINICKE, AR
VERCESI, AE
Abstract: The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate, In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these prooxidants in the presence of Ca2+ is mediated by different mechanisms.
Subject: RAT LIVER MITOCHONDRIA
COENZYME Q REDOX STATE
CALCIUM ION
REACTIVE OXYGEN SPECIES
LIPID PEROXIDATION
PROTEIN OXIDATION
FREE RADICALS
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/0891-5849(94)00098-5
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOSA1995PZ97900007.pdf473.38 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.