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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOverexpression of apolipoprotein CIII increases and CETP reverses diet-induced obesity in transgenic micept_BR
dc.contributor.authorSalerno, AGpt_BR
dc.contributor.authorSilva, TRpt_BR
dc.contributor.authorAmaral, MECpt_BR
dc.contributor.authorAlberici, LCpt_BR
dc.contributor.authorBonfleur, MLpt_BR
dc.contributor.authorPatricio, PRpt_BR
dc.contributor.authorFrancesconi, EPMSpt_BR
dc.contributor.authorGrassi-Kassisse, DMpt_BR
dc.contributor.authorVercesi, AEpt_BR
dc.contributor.authorBoschero, ACpt_BR
dc.contributor.authorOliveira, HCFpt_BR
unicamp.authorUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Campinas, SP, Brazil Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, Campinas, SP, Brazilpt_BR
dc.subjectapolipoprotein CIIIpt_BR
dc.subjectdiet-induced obesitypt_BR
dc.subjectmitochondrial respirationpt_BR
dc.subject.wosEster Transfer Proteinpt_BR
dc.subject.wosTriglyceride-rich Lipoproteinspt_BR
dc.subject.wosHypertriglyceridemic Micept_BR
dc.subject.wosCholesteryl Esterspt_BR
dc.subject.wosSelective Uptakept_BR
dc.description.abstractObjective: We recently described that hypertriglyceridemic apolipoprotein (apo) CIII transgenic mice show increased whole body metabolic rate. In this study, we used these apo CIII-expressing mice, combined or not with the expression of the natural promoter-driven CETP gene, to test the hypothesis that both proteins modulate diet-induced obesity. Measurements and results: Mice expressing apo CIII, CIII/CETP, CETP and nontransgenic (NonTg) mice were maintained on a high-fat diet (14% fat by weight) during 20 weeks after weaning. At the end of this period, all groups exhibited the expected lipemic phenotype. Fasting glucose levels were neither affected by the high-fat diet nor by the distinct genotypes. However, apo CIII mice showed significantly higher glycemia (similar to 35%) and lower insulin levels (similar to 45%) in the fed state, compared with the NonTg mice. The apo CIII mice presented significantly increased body weight, lipid content of the carcass (similar to 25%), visceral adipose tissue mass (about twofold) and adipocyte size (similar to 25%) compared with the CETP and NonTg mice. The CETP expression in the apo CIII background normalized the subcutaneous adipose depot and visceral adipocyte size to the levels of NonTg mice. Plasma leptin levels were lower in CETP groups (25 -50%) and higher in the apo CIII mice. Similar core body temperature in all groups and similar liver mitochondrial resting respiration rates in CIII and NonTg mice indicate no differences in basal energy expenditure rates among these mice fed a high-fat diet. Conclusion: The elevation of plasma apo CIII levels aggravates diet-induced obesity and the expression of physiological levels of circulating CETP reverses this adipogenic effect, indicating a novel role for CETP in modulating
dc.relation.ispartofInternational Journal Of Obesitypt_BR
dc.relation.ispartofabbreviationInt. J. Obes.pt_BR
dc.publisherNature Publishing Grouppt_BR
dc.identifier.citationInternational Journal Of Obesity. Nature Publishing Group, v. 31, n. 10, n. 1586, n. 1595, 2007.pt_BR
dc.sourceWeb of Sciencept_BR
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