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Type: Artigo de periódico
Title: Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release
Author: Seabra, AB
de Oliveira, MG
Abstract: The nitric oxide (NO) donor S-nitrosoglutathione (GSNO) was incorporated in solid polymeric films of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP) and blended PVA/PVP. These matrices were found to provide a great stabilization effect on the thermal decomposition of GSNO, leading to 8-16-fold reduction in the first-order rate constants of NO release, compared to aqueous GSNO solutions. PVA/PVP-GSNO released 90% of the NO supply, over a time period of 24 h at 37 degreesC. Differential scanning calorimetry has confirmed the miscibility between the two polymeric components. Stress-strain analysis has shown an improvement of the mechanical property of PVA films in the PVA/PVP blend, which leads to an increase of 25% in the stress at break. Scanning electron microscopy has shown that the PVA/PVP-GSNO blend leads to a smooth coating of metallic surfaces. These properties, allied to the already known good biocompatibility of PVA and PVP, makes GSNO-containing PVA and PVA/PVP blend films good candidates for the local and controlled release of NO in target areas. (C) 2003 Elsevier Ltd. All rights reserved.
Subject: S-nitrosoglutathione
nitric oxide
poly(vinyl alcohol)
poly(vinyl pyrrolidone)
NO release
Country: Inglaterra
Editor: Elsevier Sci Ltd
Rights: fechado
Identifier DOI: 10.1016/j.biomaterials.2003.10.035
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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