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|Type:||Artigo de periódico|
|Title:||Magnesium deficiency improves glucose homeostasis in the rat: studies in vivo and in isolated islets in vitro|
|Abstract:||The serum mineral levels, glucose disappearance rate (k(g)), total area under the glucose (BG) and insulin (DeltaI) curves, and static insulin secretion were compared among rats fed a Mg-deficient diet for 6 (DF-6) or 11 (DF-11) weeks, and rats fed a control diet for the same periods (CO-6 and CO-11 groups). No change in glucose homeostasis was observed among DF-6, CO-6 and CO-11 rats. DF-11 rats showed an elevated k(g) and a reduced BG and DeltaI. For evaluating the effect of supplementation, rats fed a control or Mg-deficient diet for 6 weeks were then fed a Mg-supplemented diet for 5 weeks (SCO and SDF groups respectively). The serum Mg levels in SDF rats were similar to those in CO-11 and SCO rats. but higher than in the DF-11 group. SDF rats showed similar k(g), DeltaG and DeltaI compared with the CO-11 and SCO groups. However, a significantly lower k(g) and higher DeltaG and hi were observed in SDF compared with DF-11 rats. Basal and 8.3 mmol glucose/l-stimulated insulin secretion by islets from DF-II rats were higher than by islets from CO-11 rats. These results indicate that moderate Mg depletion for a long period may increase the secretion and sensitivity to insulin, while Mg supplementation in formerly Mg-deficient rats may prevent the increase in sensitivity and secretion of insulin.|
|Editor:||C A B I Publishing|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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