Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81326
Type: Artigo de periódico
Title: Lymphocyte activation in silica-exposed workers
Author: Rocha-Parise, M
Santos, LMB
Damoiseaux, JGMC
Bagatin, E
Lido, AV
Torello, CO
Tervaert, JWC
Queiroz, MLS
Abstract: Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. (C) 2013 Elsevier GmbH. All rights reserved.
Subject: Lymphocytes
Soluble IL-2 receptor alpha
Interleukin-2
Silica
Cytokines
Autoimmunity
Country: Alemanha
Editor: Elsevier Gmbh, Urban & Fischer Verlag
Rights: fechado
Identifier DOI: 10.1016/j.ijheh.2013.11.002
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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