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Type: Artigo de periódico
Title: Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: A clinical study
Author: Machion, L
Andia, DC
Benatti, BB
Carvalho, MD
Nogueira, GR
Casati, MZ
Nociti, FH
Sallum, EA
Abstract: Background: The aim of this clinical study was to evaluate the association of locally delivered doxycycline (10%) with scaling and root planing in the periodontal treatment of smokers. Methods: Forty-three patients with chronic periodontitis and a minimum of four pockets ( 5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP-D). Plaque, bleeding on probing, gingival recession, relative attachment level (RAL), and probing depth (PD) were recorded at baseline, 45 days, and 3 and 6 months. Differences between baseline and each period were considered for analysis. Results: At 6 months, no difference was found between groups regarding plaque, bleeding reduction, gingival recession or PD (P > 0.05). However, RAL gain was greater for SRP-D (1.63 +/- 0.93 mm) than for SRP (1.04 +/- 0.71 mm) (P = 0.025). In addition, deep pockets (greater than or equal to 7 mm) showed a significant reduction (3.78 +/- 1.41 versus 2.60 +/- 1.28 mm, P = 0.039) and RAL gain (2.54 +/- 1.27 mm versus 1.29 +/- 0.95 mm, P = 0.01) when doxycycline was applied. The proportion of sites showing RAL gain of 1 to 2 mm was 36.8% versus 21.7% for SRP-D and SRP, respectively (P = 0.01). Conclusion: The use of locally delivered doxycycline may constitute an important adjunct for the treatment of severe periodontal disease in smokers.
Subject: comparison studies
doxycycline/therapeutic use
periodontal diseases/therapy
smoking/adverse effects
Country: EUA
Editor: Amer Acad Periodontology
Rights: fechado
Identifier DOI: 10.1902/jop.2004.75.3.464
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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