Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/81226
Type: Artigo
Title: Liposome-encapsulated ropivacaine for intraoral topical anesthesia
Author: Franz-Montan, M.
de Paula, E.
Groppo, F. C.
Silva, A. L. R.
Ranali, J.
Volpato, M. C.
Abstract: This study evaluated the efficacy of liposome-encapsulated 2% ropivacaine in topical anesthesia and its influence on pulpal response. Forty volunteers received the following topical formulations in the buccal fold of the maxillary lateral incisors region (bilaterally): liposome-encapsulated 2% ropivacaine gel (RL2); 20% benzocaine gel (B20); liposomal placebo gel (LP); and placebo gel (P). Formulations were kept in place for 30 minutes, during which time the teeth were electric pulp tested every 10 minutes. After this procedure, a dental needle was inserted until periosteum contact in the same site of topical application and pain was rated by a visual analog scale. Duration of soft tissue anesthesia was assessed by pinprick test. RL2 and B20 showed lower pain response to needle insertion and longer soft tissue anesthesia then P and LP (P = .0003 and P < .0001, respectively); however, RL2 was not different from B20 (P > .05) regarding those parameters. None of the formulations was able to induce pulpal anesthesia. RL2 was as effective as B20 in reducing pain during needle insertion and inducing soft tissue anesthesia; however, neither one was able to induce pulpal anesthesia after a 30-min application. ClinicalTrials.gov NCT01054547
Subject: Ropivacaína
Anestésicos locais
Lipossomas
Country: Estados Unidos
Editor: Elsevier
Citation: Oral Surgery Oral Medicine Oral Pathology Oral Radiology And Endodontology. Mosby-elsevier, v. 110, n. 6, n. 800, n. 804, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.tripleo.2010.07.005
Address: https://www.sciencedirect.com/science/article/pii/S1079210410005081
Date Issue: 2010
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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