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Type: Artigo de periódico
Title: Lipid membrane with low proton permeability
Author: Biloti, DN
Santana, MHA
Pessine, FBT
Abstract: This work reports the production of a liposomal formulation, having a lipidic membrane with known chemical composition and a low proton permeability, as confirmed by physicochemical characterization of the maintenance of a transmembranic pH gradient. These liposomes consist of DSPC, DSPE-PEG, DSPG and cholesterol, with low internal pH. To verify the low proton permeability of these liposomal bilayers, a study of proton migration according to the fluorescence quenching of 9-aminoacridine (9AA), as well as CPT-11 encapsulation, were used to monitor the acidification of the intravesicular space. Both experiments showed that this liposomal formulation is able to maintain a transmembranic proton gradient. (C) 2003 Elsevier Science B.V All rights reserved.
Subject: sterically stabilized liposome
transmembranic proton gradient
fluorescence spectroscopy
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0005-2736(03)00035-X
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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