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Type: Artigo de periódico
Title: Power of the likelihood ratio test for models of DNA base substitution
Author: Cybis, GB
Lopes, SRC
Pinheiro, HP
Abstract: The goal of thiswork is to study the properties of the likelihood ratio ( LR) tests comparing base substitution models. These are the most widely used hypothesis tests. With mild regularity conditions, we show that the asymptotic distribution of the LR statistic test, under the alternative hypothesis, is a non-central chi-square chi(2)(k) D) distribution. The asymptotic normal distribution of the LR test is proved when the sequence length S goes to infinity. We also propose a consistent estimator for the non-centrality parameter D. Through asymptotic theory and based on this consistent estimator for D, we propose a low computational cost estimator for the power of the LR test. The methodology is applied to 17 different gene sequences of the ECP-EDN family in primates.
Subject: phylogenetic inference
Monte Carlo simulation
evolutionary model
maximum-likelihood function
hypothesis test
power of the test
asymptotic distribution
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Journal Of Applied Statistics. Taylor & Francis Ltd, v. 38, n. 12, n. 2723, n. 2737, 2011.
Rights: fechado
Identifier DOI: 10.1080/02664763.2011.567253
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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