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Type: Artigo de periódico
Title: Linalool from Rosewood (Aniba rosaeodora Ducke) Oil Inhibits Adenylate Cyclase in the Retina, Contributing to Understanding its Biological Activity
Author: Sampaio, LDS
Maia, JGS
de Parijos, AM
de Souza, RZ
Barata, LES
Abstract: Rosewood oil (RO) (Aniba rosaeodora Ducke) is rich in linalool, a monoterpene alcohol, which has well studied anxiolytic, sedative and anticonvulsant effects. The inhibition of the increases in cAMP protects against seizures in a diversity of models of epilepsy. In this paper, the principal aim was to investigate the effects of RO, (+/-)-linalool and (-)-linalool) on adenylate cyclase. They were tested in chick retinas and forskolin was used to stimulate the enzyme target. The phosphodiesterase inhibitor, 4-(3-butoxy-4-methoxybenzyl)-imidazolidin-2-one, and the non-selective adenosine receptor antagonist 3-isobutyl-methyl-xanthine (IBMX), were used to control the participation of phosphodiesterase and adenosine receptors in the resulting effects, respectively. The cAMP accumulation was measured by enzyme immune assay (EIA). Rosewood oil, (-)-linalool and (+/-)-linalool inhibited exclusively the cAMP accumulation stimulated by forskolin, even when adenosine receptors were blocked with IBMX. The IC(50) values (in mu m concentration range) calculated from their concentration responsecurves were not statistically different, however, the compounds presented a different relative efficacy. These results extend the range of subcellular mechanisms underlying the relaxant action of linalool on the central nervous system. Copyright (C) 2011 John Wiley & Sons, Ltd.
Subject: Aniba rosaeodora Ducke
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/ptr.3518
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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