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Type: Artigo de periódico
Title: Limitations in determining enantiomeric excess of alcohols by P-31-NMR of the phosphonate derivatives
Author: Laverde, A
de Miranda, DS
da Conceicao, GJA
Schirmer, H
Pilli, RA
de Meijere, A
Marsaioli, AJ
Abstract: The use of diastereomeric alcohol dialkylphosphonate derivatives to determine the enantiomeric excesses via P-31-NMR signal ratios of anisochronous meso and three isomers was successfully applied to secondary alcohols (Feringa's method). Expansion of the methodology to primary alcohols possessing the hydroxyl groups thethered to the stereogenic centers by two or more methylene groups proved the method to be inefficent. The comparison between the coupled and decoupled spectra is important in order to identify the signals corresponding to the dialkylphosphonates. Nevertheless the methodology should be applied whenever the amount of the alcohol and its structure are not the limiting factors.
Subject: P-31-NMR
enantiomeric excess
chiral alcohols
phosphonate derivatives
Country: Brasil
Editor: Soc Brasileira Quimica
Citation: Journal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 10, n. 4, n. 293, n. 298, 1999.
Rights: aberto
Identifier DOI: 10.1590/S0103-50531999000400007
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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